帝京大学

濱 弘太郎 准教授

所属キャンパス板橋キャンパス

帝京大学 薬学部 薬学科

連絡先

電話番号

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経歴・所属学会・専門分野・研究テーマ

専門分野

ライフサイエンス 栄養学、健康科学、ライフサイエンス 機能生物化学

研究テーマ

脂質

教育方法・職務上の実績

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著書・論文

学術論文

Kotaro Hama, Yuko Fujiwara, Tamuro Hayama, Tsuyoshi Ozawa, Keijiro Nozawa, Keiji Matsuda, Yojiro Hashiguchi, Kazuaki Yokoyama

Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues.

2021年03月17日 | Scientific reports 11 1 6163-6163 

学術論文

Kotaro Hama, Yuko Fujiwara, Shigeo Takashima, Yasuhiro Hayashi, Atsushi Yamashita, Nobuyuki Shimozawa, Kazuaki Yokoyama

Hexacosenoyl-CoA is the most abundant very long-chain acyl-CoA in ATP binding cassette transporter D1-deficient cells.

2020年04月 | Journal of lipid research 61 4 523-536 

学術論文

Mitsuyasu Kawaguchi, Takayoshi Okabe, Shinichi Okudaira, Kotaro Hama, Kuniyuki Kano, Hiroshi Nishimasu, Hidehiko Nakagawa, Ryuichiro Ishitani, Hirotatsu Kojima, Osamu Nureki, Junken Aoki, Tetsuo Nagano

Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain.

2020年03月26日 | Journal of medicinal chemistry 63 6 3188-3204 

学術論文

Yuko Fujiwara, Kotaro Hama, Kazuaki Yokoyama

Mass spectrometry in combination with a chiral column and multichannel-MRM allows comprehensive analysis of glycosphingolipid molecular species from mouse brain.

2020年02月25日 | Carbohydrate research 490 107959-107959 

学術論文

Hayashi Y, Nemoto-Sasaki Y, Matsumoto N, Hama K, Tanikawa T, Oka S, Saeki T, Kumasaka T, Koizumi T, Arai S, Wada I, Yokoyama K, Sugiura T, Yamashita A

Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels.

2018年11月09日 | J Biol Chem 293 45 17505-17522 

学術論文

Hama K, Fujiwara Y, Yokoyama K

Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species.

2018年05月07日 | Journal of visualized experiments : JoVE 135  

学術論文

Hama K, Fujiwara Y, Morita M, Yamazaki F, Nakashima Y, Takei S, Takashima S, Setou M, Shimozawa N, Imanaka T, Yokoyama K

Profiling and Imaging of Phospholipids in Brains of Abcd1-Deficient Mice.

2018年01月 | Lipids 53 1 85-102 

学術論文

Fujiwara Y, Hama K, Tsukahara M, Izumi-Tsuzuki R, Nagai T, Ohe-Yamada M, Inoue K, Yokoyama K

Acyl Chain Preference in Foam Cell Formation from Mouse Peritoneal Macrophages.

2018年 | Biol Pharm Bull 41 1 86-91 

学術論文

Hama K, Fujiwara Y, Tabata H, Takahashi H, Yokoyama K

Comprehensive Quantitation Using Two Stable Isotopically Labeled Species and Direct Detection of N-Acyl Moiety of Sphingomyelin.

2017年09月 | Lipids 52 9 789-799 

学術論文

Tatsuji Nishioka, Naoaki Arima, Kuniyuki Kano, Kotaro Hama, Eriko Itai, Hiroshi Yukiura, Ryoji Kise, Asuka Inoue, Seok-Hyung Kim, Lilianna Solnica-Krezel, Wouter H Moolenaar, Jerold Chun, Junken Aoki

ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.

2016年03月23日 | Scientific reports 6 23433-23433 

学術論文

Keita Nakanaga, Kotaro Hama, Kuniyuki Kano, Takanao Sato, Hiroshi Yukiura, Asuka Inoue, Daisuke Saigusa, Hidetoshi Tokuyama, Yoshihisa Tomioka, Hiroshi Nishina, Atsuo Kawahara, Junken Aoki

Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo.

2014年04月 | 4 Journal of biochemistry 155 4 235-41 

学術論文

Hama K, Nagai T, Nishizawa C, Ikeda K, Morita M, Satoh N, Nakanishi H, Imanaka T, Shimozawa N, Taguchi R, Inoue K, Yokoyama K

Molecular species of phospholipids with very long chain fatty acids in skin fibroblasts of Zellweger syndrome.

2013年12月 | 12 Lipids 48 12 1253-67 

学術論文

Daisuke Saigusa, Kanako Shiba, Asuka Inoue, Kotaro Hama, Michiyo Okutani, Nagisa Iida, Masayoshi Saito, Kaori Suzuki, Tohru Kaneko, Naoto Suzuki, Hiroaki Yamaguchi, Nariyasu Mano, Junichi Goto, Takanori Hishinuma, Junken Aoki, Yoshihisa Tomioka

Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.

2012年06月 | 7 Analytical and bioanalytical chemistry 403 7 1897-905 

学術論文

Hashimoto T, Okudaira S, Igarashi K, Hama K, Yatomi Y, Aoki J

Identification and biochemical characterization of a novel autotaxin isoform, ATXδ, with a four-amino acid deletion.

2012年01月 | 1 J Biochem 151 1 89-97 

学術論文

Hiroshi Yukiura, Kotaro Hama, Keita Nakanaga, Masayuki Tanaka, Yoichi Asaoka, Shinichi Okudaira, Naoaki Arima, Asuka Inoue, Takafumi Hashimoto, Hiroyuki Arai, Atsuo Kawahara, Hiroshi Nishina, Junken Aoki

Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish.

2011年12月23日 | 51 The Journal of biological chemistry 286 51 43972-83 

学術論文

Hiroshi Nishimasu, Shinichi Okudaira, Kotaro Hama, Emiko Mihara, Naoshi Dohmae, Asuka Inoue, Ryuichiro Ishitani, Junichi Takagi, Junken Aoki, Osamu Nureki

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

2011年02月 | NATURE PUBLISHING GROUP NATURE STRUCTURAL & MOLECULAR BIOLOGY 18 2 205-U271 

学術論文

Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O

Crystal structure of autotaxin and insight into GPCR activation by lipid mediators.

2011年02月 | 2 Nat Struct Mol Biol 18 2 205-12 

学術論文

Hama K, Aoki J

LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid.

2010年10月 | 4 Prog Lipid Res 49 4 335-42 

学術論文

Clifton JD, Lucumi E, Myers MC, Napper A, Hama K, Farber SA, Smith AB, Huryn DM, Diamond SL, Pack M

Identification of novel inhibitors of dietary lipid absorption using zebrafish.

2010年08月25日 | 8 PLoS one 5 8 e12386 

学術論文

Nakanaga K, Hama K, Aoki J

Autotaxin--an LPA producing enzyme with diverse functions.

2010年07月 | 1 J Biochem 148 1 13-24 

学術論文

Endo T, Kano K, Motoki R, Hama K, Okudaira S, Ishida M, Ogiso H, Tanaka M, Matsuki N, Taguchi R, Kanai M, Shibasaki M, Arai H, Aoki J

Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.

2009年08月 | 2 J Biochem 146 2 283-93 

学術論文

Hama K, Provost E, Baranowski TC, Rubinstein AL, Anderson JL, Leach SD, Farber SA

In vivo imaging of zebrafish digestive organ function using multiple quenched fluorescent reporters.

2009年02月 | 2 Am J Physiol Gastrointest Liver Physiol 296 2 G445-53-53 

学術論文

Ouyang M, Garnett AT, Han TM, Hama K, Lee A, Deng Y, Lee N, Liu HY, Amacher SL, Farber SA, Ho SY

A web based resource characterizing the zebrafish developmental profile of over 16,000 transcripts.

2008年02月 | 3 Gene Expr Patterns : GEP 8 3 171-80 

学術論文

Hama K, Aoki J, Inoue A, Endo T, Amano T, Motoki R, Kanai M, Ye X, Chun J, Matsuki N, Suzuki H, Shibasaki M, Arai H

Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice.

2007年12月 | 6 Biol Reprod 77 6 954-9 

学術論文

Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Aoki J, Hama K, Okudaira S, Tanaka M, Tomiya T, Yanase M, Tejima K, Nishikawa T, Arai M, Arai H, Omata M, Fujiwara K, Yatomi Y

Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.

2007年07月 | 6 J Clin Gastroenterol 41 6 616-23 

学術論文

Hama K, Aoki J, Bandoh K, Inoue A, Endo T, Amano T, Suzuki H, Arai H

Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus.

2006年09月27日 | 18 Life Sci 79 18 1736-40 

学術論文

Kishi Y, Okudaira S, Tanaka M, Hama K, Shida D, Kitayama J, Yamori T, Aoki J, Fujimaki T, Arai H

Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.

2006年06月23日 | 25 J Biol Chem 281 25 17492-500 

学術論文

Yamashita H, Kitayama J, Shida D, Ishikawa M, Hama K, Aoki J, Arai H, Nagawa H

Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer.

2006年01月01日 | 1 J Surg Oncol 93 1 30-5 

学術論文

Masuda Y, Itabe H, Odaki M, Hama K, Fujimoto Y, Mori M, Sasabe N, Aoki J, Arai H, Takano T

ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells.

2006年01月 | 1 J Lipid Res 47 1 87-98 

学術論文

Xu Y, Aoki J, Shimizu K, Umezu-Goto M, Hama K, Takanezawa Y, Yu S, Mills GB, Arai H, Qian L, Prestwich GD

Structure-activity relationships of fluorinated lysophosphatidic acid analogues.

2005年05月05日 | 9 J Med Chem 48 9 3319-27 

学術論文

Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Kennedy G, Arai H, Aoki J, Chun J

LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing.

2005年05月05日 | 7038 Nature 435 7038 104-8 

学術論文

Shida D, Kitayama J, Yamaguchi H, Hama K, Aoki J, Arai H, Yamashita H, Mori K, Sako A, Konishi T, Watanabe T, Sakai T, Suzuki R, Ohta H, Takuwa Y, Nagawa H

Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells.

2004年12月10日 | 2 Exp Cell Res 301 2 168-78 

学術論文

Shida D, Watanabe T, Aoki J, Hama K, Kitayama J, Sonoda H, Kishi Y, Yamaguchi H, Sasaki S, Sako A, Konishi T, Arai H, Nagawa H

Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer.

2004年10月 | 10 Lab Invest 84 10 1352-62 

学術論文

Tamaruya Y, Suzuki M, Kamura G, Kanai M, Hama K, Shimizu K, Aoki J, Arai H, Shibasaki M

Identifying specific conformations by using a carbohydrate scaffold: discovery of subtype-selective LPA-receptor agonists and an antagonist.

2004年05月17日 | 21 Angew Chem Int Ed Engl 43 21 2834-7 

学術論文

Hama K, Aoki J, Fukaya M, Kishi Y, Sakai T, Suzuki R, Ohta H, Yamori T, Watanabe M, Chun J, Arai H

Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.

2004年04月23日 | 17 J Biol Chem 279 17 17634-9 

学術論文

Kitayama J, Shida D, Sako A, Ishikawa M, Hama K, Aoki J, Arai H, Nagawa H

Over-expression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma.

2004年 | 6 Breast Cancer Res 6 6 R640-6-6 

学術論文

McIntyre TM, Pontsler AV, Silva AR, St Hilaire A, Xu Y, Hinshaw JC, Zimmerman GA, Hama K, Aoki J, Arai H, Prestwich GD

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist.

2003年01月07日 | 1 Proc Natl Acad Sci U S A 100 1 131-6 

学術論文

Aoki J, Taira A, Takanezawa Y, Kishi Y, Hama K, Kishimoto T, Mizuno K, Saku K, Taguchi R, Arai H

Serum lysophosphatidic acid is produced through diverse phospholipase pathways.

2002年12月13日 | 50 J Biol Chem 277 50 48737-44 

学術論文

Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, Yamori T, Mills GB, Inoue K, Aoki J, Arai H

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.

2002年07月22日 | 2 J Cell Biol 158 2 227-33 

学術論文

Hama K, Bandoh K, Kakehi Y, Aoki J, Arai H

Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.

2002年07月17日 | 1-3 FEBS lett 523 1-3 187-92 

その他

TM McIntyre, AV Pontsler, AR Silva, AS St Hilaire, Y Xu, JC Hinshaw, GA Zimmerman, K Hama, J Aoki, H Arai, GD Prestwich

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPAR gamma agonist (vol 100, pg 131, 2002)

2003年02月 | NATL ACAD SCIENCES PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 4 2163-2163