帝京大学
安部 良

安部 良 特任教授

ABE RYO

所属キャンパス板橋キャンパス

研究所・センター 戦略的イノベーション研究センター

連絡先

メールアドレス

電話番号

03-3964-9402

FAX番号

03-3964-9403

経歴・所属学会・専門分野・研究テーマ

経歴

1978年03月

帝京大学医学部 卒業

1978年04月

~1978年 河北病院(現河北総合病院)内科医師(常勤)
~1985年(非常勤)

1983年03月

東京大学大学院医学研究科第三基礎医学(免疫学専攻)修了 医学博士

1983年04月

~1985年 東京大学助手(医学部免疫学教室)

1985年01月

~1988年 米国国立衛生研究所(NIH)、国立がん研究所(NCI)、免疫部門 Postdoctoral Fellow

1987年01月

~1989年 米国国立衛生研究所(NIH)、国立がん研究所(NCI)、免疫部門 Visiting Associate

1989年01月

~1992年 米国国立衛生研究所(NIH)、国立がん研究所(NCI)、免疫部門 Investigator

1993年01月

~2004年 米国国立衛生研究所(NIH)、国立がん研究所(NCI)、免疫部門 Visiting Researcher

1993年01月

~1997年 米国国立海軍医学研究所免疫細胞生物学部門免疫部部長

1993年01月

~1997年 Uniformed Services University of the Health Science 医学部准教授(内科学、病理学)

1995年04月

~2018年 東京理科大学生命科学研究所(現生命医科学研究所)免疫生物学研究部門 教授

2001年04月

~2008年 東京理科大学ゲノム創薬研究センターシグナル制御部門長

2004年04月

~2006年 長崎大学大学院医学研究科非常勤講師

2006年04月

~2014年 東京理科大学薬学部教授

2007年01月

~2016年 東京理科大学生命科学研究所(現生命医科学研究所)所長

2007年01月

~2016年 東京理科大学大学院生命科学研究科長

2008年01月

~2016年 東京理科大学評議員

2009年04月

~2013年 東京理科大学がん医療基盤科学技術研究センター長

2012年01月

~2016年 東京理科大学理事

2013年10月

~2018年 東京理科大学総合研究機構 医理工連携研究部門長

2014年04月

~現在 早稲田大学人間科学学術院非常勤講師

2015年04月

~2018年 帝京大学医療共通教育研究センター客員教授

2018年04月

~現在 帝京大学戦略的イノベーション研究センター特任教授

2018年04月

~現在 東京理科大学名誉教授

所属学会

米国免疫学会

日本免疫学会

日本がん学会

日本アレルギー学会

日本インターフェロン・サイトカイン学会

専門分野

細胞免疫学
臨床免疫学
腫瘍免疫学
アレルギー学
細胞内シグナル伝達

研究テーマ

主要な研究内容

東京大学医学部免疫学教室 (多田富雄教授)
T細胞による免疫応答の調節機構の研究

米国国立衛生研究所(NIH)、 国立癌研究所(NCI)免疫部門
マウスの内因性スーパー抗原、Mls遺伝系の解明とT細胞レパートリー形成機構の解析
T細胞活性化機構の解析

米国国立海軍医学研究所(NMRI) 免疫細胞生物学部門
各種免疫応答におけるCD28補助シグナル機能解析
細菌性スーパー抗原による宿主免疫機能の破綻

東京理科大学生命科学研究所
T細胞補助シグナル制御による自己免疫疾患、アレルギー反応、移植臓器拒絶反応などの免疫病の治療法の開発
がんの免疫療法の開発
難治性がん治療に対する中性子捕捉療法(BNCT)の臨床展開

教育方法・職務上の実績

職務上の実績

日本語論文・総説 58報

招待講演(学術) 40回

一般向け講演   36回

一般向け著書
2014年2月  病弱体質は変えられる (単著)すばる舎
2011年7月  免疫力アップジュース 大越/郷子著 安部良監修  西東社
2007年7月  体をまもる仕組み辞典 (監修) 成美堂出版
2007年2月  免疫力アップレシピ  (監修)
       コナミデジタルエンタテイメント
2005年1月  免疫力を高めるいきいき健康法 (共著)安部良 則岡孝子
       PHP研究所
2001年7月  免疫のしくみ    (単著) PHP研究所

テレビ、ラジオ出演、取材ほか
2002.8 フジテレビ健康番組「免疫の神秘」
2002.10.9  NHK 生活ホットモーニング 「からだはエライ!病から身を守る 免疫」出演
2002.11  関西テレビ 発掘!あるある大辞典 「春の血液診断スペシャル」取材
2002.12.15 関西テレビ 発掘!あるある大辞典 「ウィルス」インタビュー
2003.3  関西テレビ 14:30~「健康スクープ 花粉症対策教えてちょうだい!!」取材
2003.4 紀伊国屋書店ビデオ「入門・ゲノム科学」(全3巻)第3巻「遺伝子と病気」 ビデオ資料提供
2003.9 学研ベーグル11月号電話取材 「秋からのアレルギー性鼻炎対策、最新情報」
2003.10.3 NHK総合 16:05~16:45 ハツラツ道場 「弱ってませんか?免疫力②疑問一挙解決」出演
2004.5.9 教育テレビ18:00~18:45 NHKジュニアスペシャル「驚異の小宇宙・人体  第3集 生命を守れ!ミクロの戦士たち」(12.26再放送)
2004.8.20  NHK生活ホットモーニング出演
「からだはエライ!スペシャル 脳から元気になろう、免疫力アップ!脳をストレスから守れ」
2009.10.17,10.24,10.31 BS-TBS からだのミカタ #66「免疫力UP法」出演
2009.10.24 7:00~7:30 NHK総合『おはよう日本』(枠内にて放送)
「食事によって免疫力を高めるにはどうしたらよいか」
2009.11.5,12,26 7:00~9:00   RKB毎日放送 ラジオ 
「中西一清スタミナラジオ」のスタミナ健康相談所というコーナーに‘免疫力’ について対話形式インタビュー出演 
2010.1.24 18:30~18:56 テレビ朝日
「奇跡の地球物語~近未来創造サイエンス~」
#014「人体1 免疫システム 花粉症はなぜ起きるか?」取材
2012.6.19 8:45~9:15 TBSテレビ はなまるマーケット 
とくまるコーナー「レタスを美味しく食べて免疫力アップ」でインタビュー出演
2014.8.13  TBSラジオ電話出演
生島ヒロシのおはよう一直線「丈夫な体に変わる習慣」について
2015.1.4,18 TBSテレビ 「駆け込みドクター!」出演
2016.1.24 TBSテレビ 「健康カプセル!元気の時間」出演

新聞記事
安部 良:T細胞補助シグナル分子 薬事日報 第9740号 薬事日報社(2003.4)
安部 良:「免疫力低下」日本経済新聞 夕刊9面(生活)記事 (2014.4.3)
安部 良:「4日投与、長く免疫抑制」 日経産業新聞 (2014.5.8)
安部 良、小幡裕希、椎名 勇 新聞記事:日刊工業新聞 朝刊35面(2017.4.21)
見出し「新しい分子標的薬を合成 がん増殖抑制に効果」
安部 良、小幡裕希、椎名 勇 新聞記事:薬事日報 朝刊24面(2017.4.21)
見出し「M-COPA 難治性血液癌治療薬の候補 マスト細胞腫の無限増殖を抑制」
安部 良、小幡裕希、椎名 勇 新聞記事:日経産業新聞 008ページ(2017.4.26)
見出し「マスト細胞腫 増殖抑える 東京理科大 白血病薬開発に道」
東京理科大学チーム開発(椎名 勇他)新聞記事:読売新聞 朝刊15面(2017.5.14)
見出し「抗がん剤候補物質 血液がん抑制効果」
安部 良、小幡裕希、椎名 勇 新聞記事:フジサンケイビジネスアイ 朝刊9面(2017.5.27)
     大学発日本人と技術―日本を支える研究活動と技術開発― 見出し「マスト細胞腫無限増殖に対しM-COPAが阻害効果」




著書・論文

学術論文

Wakamatsu, E and Abe, R. (2018) The gut microbiota positively regulates anti-tumor immune responses through the activation of CD8+ T cells. (2019)

| ADC letter for Infectious Diseases (in press) 

学術論文

Tamori, S., Nozaki, Y.., , , Abe, R., , , and Akimoto,K (2018) Glyoxlase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells.

| Oncotarget, 9(92):365151-36529 

学術論文

Shirasago, Y, Fukazawa, H., Aizaki, H., Suzuki, T., Wakita, T., Hanada, K., Abe, R., and Fukasawa, M (2018) Thermostable hepatitis C virus JFH1-derived variant isolated by adaptation to Huh7.5.1 cell

| J. General Virology (in press) 

学術論文

Wakamatsu, E., Omori, H.,Kawano, A., Ogawa, S. and Abe, R.(2018) Strong TCR stimulation promotes the stabilization of Foxp3 expression in regulatory T cells induced in vitro through increasing the demethylation of Foxp3 CNS2.

| BBRC (in press) 

学術論文

Wakamatsu, E., Omori, H., Ohtsuka, S., Ogawa, S., Green., J. M., and Abe, R. (2018) Regulatory T cell subsets are differentially dependent on CD28 for their proliferation.

| Mol. Immunol. (in press) 

学術論文

Shashini, B, Ariyasu, S., Takeda, R., Suzuki, T., Shiina S., Akimoto, A. Maeda. T, Aikawa, N, Abe, R., Osaki, T., Itoh, N, and Aoki, S. (2018) Size-Based differentiation of cancer and normal cells by a particle size analyzer assisted by a cell-recogn

| Biol, Pharm. Bull. 41:487-503 

学術論文

Ohtsuka, J., Oshima, H., Ezawa, I. Abe, R. Oshima, and M, Ohki, R. (2018) Functional loss of p53 cooperates with the in vivo microenvironment promote malignant progression of gastric cancers

| Scientific Reports 8:2291 DOI: 10.1038 

学術論文

Wakamatsu, E., Omori, H.,Tabata, Y., Akieda, Y., Watanabe, S., Ogawa, S., and Abe, R. (2018) CD28 co-stimulation os dispensable for the steady state homeostasis of intestinal regulatory T cells.

| Int. Immunol. 30(4):171-180. 

学術論文

Obata, Y., Horikawa, K., Shiina, I., Takahashi, T., Esumi, H., Nishida, T. and Abe, R. . (2018). Oncogenic Kit signaling on the Golgi is suppressed by blocking the secretory trafficking with M-COPA in gastrointestinal stromal tumors.

| Cancer Letters 415:1-10 

学術論文

Nozaki, Y., Tamori, S., Inada, M., Katayama, R., Nakane, H., Minamishima, O., Onodera, Y., Abe, M., Shiina, S., Tamura, K., Kodama, D., Sato, K., Hara, Y., Abe, R., Takasawa, R., Yoshimori, A., Shinomiya, N., Tanuma, S., and Akimoto, K. (2017). Corr

| Genes & Cancer 8(7-8):628-639 

学術論文

Hara, Y., Obata, Y., Horikawa, K., Tasaki, Y., Suzuki, K., Murata, T., Shiina, I., and Abe, R. (2017). M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells.

| PLOS One 12(4) e0175514 

学術論文

Tanamachi, K., Nishino, Mori, N., Suzuki, T., Tanuma, SI., Abe, R., and Tsukimoto,M. (2017). Radiosensitizing Effect of P2X7 Receptor Antagonist on Melanoma in vitro and in vivo.

| Biol. Pharm. Bull. Vol.40 No.6 878-887 

学術論文

Toyoshima,S., Wakamatsu1, E., Ishida, Y., Obata, Y., Kurashima, Y., Kiyono, H. and Abe R. (2017). The spleen is the site where mast cells are induced in the development of food allergy.

| Int. Immunol. 29(1):31-45 

学術論文

Obata, Y., Horikawa, K., Takahashi, T., Akieda, Y., Tsujimoto, M., Ðonathan Alfred Fletcher, Esumi, H., Nishida, T. and Abe, R. (2017). Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal

| Oncogene 36(26):3661-3672 

学術論文

Inaba, S., Numoto, N., Ogawa, S., Morii, H., Ikura, T., Abe, R., Ito, N. and Oda, M. (2017). Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adapto

| JBC 292(3):1052-1060 

学術論文

Hisamatsu, Y., Suzuki, N., Abdullah-Al Masum, Shibuya, A., Abe, R., Sato, A., Tanuma, S. and Aoki, S. (2017). Cationic Amphiphilic Tris-Cyclometalated Iridium(III) Complexes Induce Cancer Cell Death via Interaction with Ca2+-Calmodulin Complex.

| Bioconjugate Chem. 28(2):507-523 

学術論文

Ohtsuka, S., Ogawa, S., Wakamatsu, E., and Abe, R. (2016). Cell cycle arrest caused by MEK/ERK signaling is a mechanism for suppressing growth of antigen-hyperstimulated effector T cells.

| Int. Immunol. 28 (11):547-557 

学術論文

Iida, S., Tsuda, H., Tanaka, T., Kish, DD., Abe, T., Su, CA., Abe, R., Tanabe, K., Valujskikh, A., Baldwin, WM 3rd., and Fairchild, RL. (2016). IL-1 Receptor Signaling on Graft Parenchymal Cells Regulates Memory and De Novo Donor-Recactive CD8 T Cel

| J Immunol. 196(6):2827-37. 

学術論文

Tanaka, T., Araki, R. Saido, T, Abe, R., and Aoki, S. (2016) . 11B NMR/MRI Sensing of Copper (II) Ions in Vitro by the Decomposition of a Hybrid Compound of a nido-0-Carborane and Metal Chelator.

| Eur. J. Inorg. Chem. Vol.2016 Issue 20:3330-3337 

学術論文

Tanaka, T., Nishiura, Y., Araki, R. Saido, T, Abe, R., and Aoki, S. (2016). 11B NMR Probes of Copper (II): Finding and Implications of the Cu2-Promoted Decomposition of ortho-Carborane Derivatives

| Eur. J. Inorg. Chem. 2016, 1819-1834 

学術論文

Kunishige T., Taniguchi H., Terada M.., Akiba H., Yagita H., Abe R. and Hori J. (2016). Protective role of ICOS and ICOS ligand in Cormeal Transplantation and in maintenance of immune privilege.

| Invest. Ophthalmol Vis Sci. 57(15):6815-6823 

学術論文

Suzuki T., Kishimoto H., and Abe, R. (2016). Requirement of Interleukin-7 signaling for anti-tumor immune response under lymphopenic conditions in a murine lung carcinoma model.

| Cancer Immunology, Immunotherapy 65(3), 341-345  

学術論文

Abe, A., Tani-ichi, S., Shitara, S., Cui, G., Yamada, H., Miyachi, H., Kitano, S., Hara, T., Abe, R., Yoshikai, Y., and Ikuta, K. (2015). An enhancer of the IL-7 receptor alpha-chain locus controls IL-7 receptor expression and maintenance of periphe

| J. Immunol., 195(7):3129-38. 

学術論文

Makinoshima, H., Takita, M., Saruwatari, K., Umemura, S., Obata, Y., Ishii, G., Matsumoto, S., Sugiyama, E., Ochiai, A., Abe, R., Goto, K., Esumi, H., and Tsuchihara, K.(2015). Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/ Mammalian T

| J. Biol. Chem. 290(28):17495-504 

学術論文

Okano, H., Konishi, T., Suzuki, T., Suzuki, T., Ariyasu, S., Aok, S., Abe, R., and Hayase, M. (2015). Enrichment of circulating tumor cells in tumor-bearing mouse blood by a deterministic lateral displacement microfluidic device.

| Biomedical Microdevices 17(3):9964  

学術論文

Hisamatsu, Y., Shibuya, A., Suzuki, N., Suzuki, T., Abe, R., and Aoki, S. (2015). Design and Synthesis of Amphiphilic and Luminescent Tris-Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Inducers and Detectors of Cell Death via

| Bioconjugate chemistry 20;26(5):857-79. 

学術論文

Aoki, S., Tanaka, T., Tsukimoto, M., Mori, N., Nishino, K., Tanamachi, K., Abe, R., Suzuki, T., Ogawa, S., Wakamatsu, E., Horie, K., Sakurai, Y., Tanaka, H., and Ono, K. (2015). Establishment of Innovative Combination Therapy with Boron Neutron Capt

| Reactor (KUR) Progress Report  

学術論文

Shirasago, Y., Sekizuka, T., Saito, K., Suzuki, T., Wakita, T., Hanada, K., Kuroda, M., Abe, R. and Masayoshi Fukasawa (2015). Isolation and Characterization of A Huh.7.5.1-Derived Cell Clone Highly Permissive to Hepatitis C Virus.

| Jap. J. Inf. Dis 68(2):81-8 

学術論文

Tanida, I., Shirasago, Y., Suzuki, R., Abe, R., Wakita, T., Hanada, K., and Fukasawa, M. (2015). Caffeic acid, a coffee-related organic acid, inhibits the propagation of hepatitis C virus.

| Jpn. J. Infect. Dis. 

学術論文

Akieda Y., Fujimura, K., Oka, T., Ishida, Ogawa, S., Abe, R. (2015). Defects in Regulatory T Cells Due to CD28 Deficiency Induce a Qualitative Change of Allogeneic Immune Response in Chronic Graft-versus-Host Disease.

| J. Immunol. 194(9)4162-4174 

学術論文

Shimizu, R., Umezawa, M., Okamoto, S., Onoda, A., Uchiyama, M., Tachibana, K., Watanabe, S., Ogawa, S., Abe, R., Takeda, K. (2014). Effect of maternal exposure to carbon black nanoparticle during early gestation on the splenic phenotype of neonatal

| J. Toxicol. Sci. 39, 571-57 

学術論文

Obata, Y., Toyoshima, S., Wakamatsu, E., Suzuki, S., Esumi, H. and Abe, R.(2014). Oncogenic Kit signaling on endolysosomes and the endoplasmic reticulum is essential for neoplastic mast cell proliferation.

| Nat. Commun 10;5:5715 

学術論文

Higo, K., Oda, M., Morii, H., Takahashi, J., Harada, Y., Ogawa, S., and Abe, R. (2014). Quantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K.

| Immunol. Invest. 43(3):278-91 

学術論文

Kutsuzawa, K., Suzuki, T., Kishimoto, H., Murakami, A., Azuma,T., Abe ,R., and Otsuka, H. (2014). Highly robust protein production by co-culture of CHO spheroids layered on feeder cells in serum-free medium.

| Colloid and Polymer Science 292:839-848 

学術論文

Kutsuzawa, K., Takahashi, C., Sato, R., Suzuki, T., Kishimoto, H., Murakami, A., Azuma, T. and Abe, R. and Otsuka, H. (2013). Multiarray formation of CHO spheroids cocultured with feeder cells for highly efficient protein production in serum-free me

| J. Nanosci. Nanotechnol. 13, 229-235. 

学術論文

Higo, K, Ikuta, T, Oda, M., Morii, H., Takahashi, J., Abe, R. and Ito, N. (2013). High Resolution Crystal Structure of the Grb2 SH2 Domain with a Phosphopeptide Derived from CD28.

| PLOS ONE 8(9):e74482 

学術論文

Ogawa, S., Ito, N., Watanabe, S., Watanabe, M., Inutake, Y., Sakurai, Y., Harada, Y., Kishimoto H., and Abe, R. (2013). CD28 signaling in primary CD4+ T cells: Identification of both tyrosine phosphorylation-dependent and independent pathway.

| Int. Immunol. 25(12):671-81 

学術論文

Iida, S., Suzuki, T., Tanabe, K., A. Valujskikh, R. L. Fairchild and Abe, R. (2013). Transient lymphopenia breaks costimulatory blockade-based peripheral tolerance and initiates cardiac allograft rejection.

| Am. J. Transplantation 13(9)2268-79  

学術論文

Moromizato,S., Hisamitsu, Y., Suzuki, T., Matsuo, Y., Abe, R., and Aoki, S.(2012). Design and synthesis of a luminescent cyclometalated iridium(III) complex having N,N-diethylamino group that stains acidic intracellular organelles and induces cell de

| Inorg Chem. 3;51(23):12697-706. 

学術論文

Ariyasu , S, Hanaya, K, Watanabe, E, Suzuki, T., Horie, K, Hayase, M., Abe, R, and Aoki, S. (2012). The selective capture and collection of live target cells using a photoreactive silicon wafer device modified with antibodies via a photocleavable li

| Langmuir 28:13118-26 

学術論文

Watanabe, M., Nakajima, S, Ohnuki, K., Ogawa S., Yamashita, M., Nakayama, T., Murakami Y., Tanabe, K. and Abe, R. (2012). AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling.

| Eur. J. Immunol. 42(7):1850-62 

学術論文

Iida, S., Omoto, K., Kanemitsu, I., Setoguchi, I., Ishida, H., Tanabe, K., Suzuki, T., Tashiro, Y., Kishimoto, H., and Abe, R. (2012). Interlerkin-6 receptor signaling disruption prevents cardiac allograft deterioration by in mice.

| Exp. Clin. Transplant. 10(4):375-85 

学術論文

Kitamura, M., Suzuki, T., Abe, R., Ueno, T. and Aoki, S. (2011). 11B NMR Sensing of d-Block Metal Ions in Vitro and in Cells Based on the Carbon–Boron Bond Cleavage of Phenylboronic Acid-Pendant Cyclen (Cyclen = 1,4,7,10-Tetraazacyclododecane).

| Inorganic Chemistry 50(22):11568-11580 

学術論文

Ariyasu, S., Hanaya, K., Tsunoda, M., Kitamura, M., Hayase, M., Abe, R., and Aoki, S. (2011). Photochemical Cleavage Reaction of 8-Quinolinyl Sulfonates that are Halogenated and Nitrated at the 7-Position.

| Chem. Pharm. Bull 59:1355-62 

学術論文

Yamano, T., Watanabe, S., Hasegawa, H., Suzuki, T., Abe, R., Tahara, H., Nitta, T., Ishimaru, N., Sprent, J., and Kishimoto, T. (2011). Ex-vivo expanded DC induce donor-specific central and peripheral tolerance and prolong the acceptance of donor ski

| Blood 117(9):2640-2648 

学術論文

Setoguchi, K., Kishimoto, H., Kobayashi S., Shimmura H., Ishida, H., Toki, D., Suzuki, T., Ohnuki, K., Tate, Y., Fujioka, S., Abe, R., and Tanabe, K. (2010). Potential role of host effector memory CD8+ T cells in marrow rejection after mixed chimeri

| Transpl. Immunol. 23(4):194-203 

学術論文

Watanabe, S.,Ohnuki, K., Hara, Y., Ishida, Y., Ikarashi, Y., Ogawa, S., Kishimoto, H., Tanabe, K., and Abe, R. (2010). Suppression of Con A-induced hepatitis induction in ICOS-deficient mice.

| Immunology Letters 128:51-58 

学術論文

Ohnuki, K., Watanabe, Y., Takahashi, Y., Kobayashi, S., Watanabe, S., Ogawa, S., Kotani, M., Kozono, H., Tanabe, K., and Abe, R. (2009). Antigen specific CD4+ effector T cells: Analysis of factors regulating clonal expansion and cytokine production.

| BBRC 380:742-747 

学術論文

Takeda, K., Harada, Y., Watanabe, R., Inutake, Y., Ogawa, S., Onuki, K., Kagaya, S., Tanabe, K., Kishimoto, H., and Abe, R. (2009). CD28 stimulation triggers NF-kB activation through CARMA1-PKCθ-Grb2/Gads axis.

| Int. Immunol. 20:1507-1515 

学術論文

Kitazawa, Y., Fujino, M., Sakai, T., Azuma, H., Kimura, H., Isaka, Y., Takahara, s., Hunig, T., Abe, R., and Li, X-K. (2008). Foxp3-expressing regulatory T cells expanded with CD28 superagonist antibody can prevent rat cardiac allograft rejection.

| J. Heart Lung Tranplant. 27:362-71 

学術論文

. Watanabe, M., Takagi, Y., Kotani, M., Hara, Y., Inamine, A., Hayashi, K., Ogawa, S., Takeda, K., Tanabe, K., and Abe, R. (2008). Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses.

| J. Immunol. 180:5222-5234 

学術論文

Suzuki, T., Ogawa, S. Tanabe, K., Tahara, T. Abe, R. and Kishimoto, H. (2008). Induction of antitumor immune response by homeostatic proliferation and CD28 signaling.

| J. Immunol. 180:4596-4605 

学術論文

Shimizu, T, Osaka, Y., Banri-Koike, C., Yoshida, M., Endo, K., Furukawa, K., Oda, M., Murakami, A., Ogawa, S., Abe, R., and Azuma, T. (2007). T cells specific to hapten-carrier but not to carrier alone assist in the production of anti-hapten and ant

| Int. Immunol. 19:1157 

学術論文

Kubota, M, Hayashi, T., Iwasaki, K., Ohtsuka, H., Kohiruimaki, M., S. Kawamura, S., Sakaguchi, K, and Abe, R, (2007). Rapid and effective method for separation of Staphylococcus aureus from somatic cells in mastitis milk.

| Journal of Dairy Science Vol90.No.9:4100-4107 

学術論文

Kitazawa, Y., Fujino, M., Wang, Q., Kimura, H., Azuma, M., Kubo, M., Abe, R., Xiao-Kang Li. (2007). Involvement of the Programmed Death-1/Programmed Death-1 Ligand Pathway in CD4+CD25+Regulatory T-Cell Activity to Suppress Alloimmune Responses.

| Transplantation 27:83(6) 

学術論文

Zhao, J., Hayashi, T., Saarinen, S., Papageorgiou, AC., Kato, H., Imanishi, K., Kirikae, T., Abe, R., Uchiyama, T., and Miyoshi-Akiyama, T.(2007). Cloning, expression and characterization of the superantigen streptococcal pyrogenic exotoxing-G from

| Infect Immun. 75(4):1721-9 

学術論文

Ohtsuka H, Kohiruimaki M, Hayashi T, Katsuda K, Matsuda K, Masui M, Abe R, Kawamura S.(2006). Relationship between Leukocyte Population and Nutritive Conditions in Dairy Herds with Frequently Appearing Mastitis.

| J Vet Med Sci. 68(2):113-8. 

学術論文

Ohtsuka, H., Watanabe, C., Kohiruimaki M., Ando, T., Watanabe D., Masui, M., Hayashi, T., Abe, R., Koiwa, M., Sato, S., and Kawamura, S. (2006). Compare to Changes in Peripheral Blood Mononuclear Cell in Periparturient Dairy Cows between Two Differe

| J. Vet. Med. Sci. 68(11):1161-6, 

学術論文

Shimmura, H., Tanabe, K., Habiro. K., Abe, R., and Toma, H. (2006). Combined effect of mycophenolate mofetil with mizoribine on cell proliferation assays in a mouse heart transplantation model.

| Transplantation. 82(2):175-9 

学術論文

Watanabe, R., Harada, Y., Takeda, K., Takahashi, J., Ohnuki, K., Ogawa, S., Ohgai, D., Kaibara, N., Koiwai, O., Tanabe, K., Toma, H., Sugamura, K., and Abe, R. (2006). Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in

| J. Immunol. 177:1085-1091 

学術論文

Watanabe, S., Ogawa, S., Hara, Y., Tanabe, K. Toma, H., and Abe, R. (2006). Expression level of costimulatory receptor ICOS is critical for determining the polarization of helper T cell function.

| Transplant Immunology 15:255-263 

学術論文

Nagai, H., Kubo, M., Abe, R., Yamamoto, M., and Nohara, K. (2006). Constitutive activation of the aryl hydrocarbon receptor in T-lineage cells induces thymus involution independently of the Fas/Fas ligand signaling pathway.

| Int. Immunopharmacol. 6:279-286 

学術論文

Kotani, M., Hirata, K., Ogawa, S., Habiro, K., Ishida, Y., Tanuma, S., Horai, R., Iwakura, Y., Kishimoto, H., and Abe, R. (2006). CD28-depnedent differentiation into the effector/memory phenotype is essential for induction of arthritis in interleuki

| Arthritis & Rheumatism 54(2):473-481 

学術論文

Williams, J.A., Hathcock, K.S., Klug D., Harada, Y. Choudhury, B., Allison, J.P. Abe, R, and Hodes, R.J. (2005). Regulated costimulation in the thymus is critical for T cell development: Dysregulated CD28 costimulation can bypass the pre-TCR checkp

| J. Immunol. 175:4199-4207 

学術論文

Tsukada, J., Ozaki, A., Hanada, T., Chinen, T., Abe, R., Yoshimura, A., and Kubo, M. (2005). The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8+ dendritic cell subset.

| Int. Immunol. 17:1167-1178 

学術論文

Takahashi Y., Inamine A., Hashimoto S., Haraguchi S., Yoshioka E., Kojima N., Abe R. and Takemori, T. (2005). Novel Role of the Ras Cascade in Memory B Cell Response.

| Immunity 23:127-138  

学術論文

Nagai H., Takei T., Tohyama C., Kubo M., Abe R., and Nohara K. (2005). Search for the target genes involved in the suppression of antibody production by TCDD in C57BL/6 mice.

| Int Immunopharmacol. 5(2):331-43 

学術論文

Ohtsuka H., Fukunaga N., Fukuda S., Hatsugaya A., Hayashi T., Hara H., Koiwa M., Abe R., and Kawamura S. (2005). Effect of nutritional conditions on changes in leukocyte populations in Japanese black calves.

| J Vet Med Sci. 67(2):183-5 

学術論文

Inamine A., Takahashi Y., Baba N., Miyake K., Tokuhisa T., Takemori T. and Abe R. (2005). Two waves of memory B cell generation in the primary immune response.

| Int. Immunol. 17 (5):581-589 

学術論文

Habiro K., Shinmura, H., Kobayashi, S., Kotani, M., Ishida, Y., Tanabe, K., Toma, H., and Abe, R. (2005). Effect of inflammation on costimulation blockade-resistant allograft rejection.

| Am. J. Transplantat 5:702-11 

学術論文

Watanabe, M., Hara, U., Tanabe, K. Toma, H.,and Abe, R. (2005). A distinct role for ICOS-mediated co-stimulatory signaling in CD4+ and CD8+ T cell subsets.

| Int. Immunology 17:269-278 

学術論文

Watanabe, M., Watanabe, S., Hara, Y., Harada, Y., Kubo, M., Tanabe, K. Toma, H., and Abe, R. (2005). ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling.

| J. Immunol. 174:1989-1996 

学術論文

Horai, R., Nakajima, A., Habiro, K., Kotani, K., Nakae, S., Matsuki, T., Nambu, A., Saijo, S., Kotaki, H., Sudo, K., Okahara, A., Tanioka, H., Ikuse, T., Ishii, N., Schwartzberg, PL., Abe, R. and Iwakura, Y. (2004). TNF- is crucial for the develop

| J. Clin. Invest. 114:1603-1611 

学術論文

Sanchez-Lockhart M., Marin E., Graf B., Abe R., Harada Y., Sedwick C., and Miller J. (2004). Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways.

| J. Immunol. 173:7120-7124 

学術論文

Okano K., Nitta K., Ogawa S., Horita S., Habiro K., Nihei H., and Abe R. (2004). Effects of double blockade of CD28 and inducible-costimulator signaling on anti-glomerular basement membrane glomerulonephritis.

| J Lab Clin Med 144(4): 183-192, 

学術論文

Tokoyoda, K., Tsujikawa, K., Matsushita, H., Ono, Y., Hayashi, T., Harada, Y., Abe, R., Kubo, M., and Yamamoto, H. (2004). Up-regulation of IL-4 production by the activated cAMP/ cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-s

| Int. Immunol. 16:643-653 

学術論文

Okamoto, N., Tezuka, K., Kato, M., Abe, R., and Tsuji, T. (2003). PI3-kinase and map-kinase signaling cascades in AILIM/ICOS and CD28-costimulated T-cells have distinct functions between cell prolifieration and IL-10 production.

| BBRC 310:691-702 

学術論文

Miyahira, Y., Akiba, H., Ogawa, S., Ishi, T., Watanabe, S., Kobayashi, S., Takeuchi, T., Aoki, T., Tezuka, K., Abe, R. Okumura, K., Yagita, H. and Watanabe, N. (2003). Involvement of ICOS-B7RP-1 costimulatory pathway in regulating immune responses to

| Immunology letters 89:193-199 

学術論文

Habiro, K., Kotani, M., Omoto, K., Kobayashi, S., Tanabe, K., Shimmura, H., Suzuki, K., Hayashi, T., Toma, H., and Abe, R. (2003). Mechanism of allorecognition and skin graft rejection in CD28- and CD40L-double deficient mice.

| Transplantation 76:854-859 

学術論文

Nitta, K., Horita, S., Ogawa S., Matsumoto, M., Hara, Y., Okano, K., Hayashi, T., Abe, R., and Nihei, H. (2003). Resistance of CD28-deficient mice to autologous phase of anti-glomerular basement membrane glomerulonephritis.

| Clin Exp Nephrol 7:104-112 

学術論文

Monze, M., Kato, H., Hayasi, T., Abe, R., Moyoshi-Akiyama, T., Uchiyama, T. and Imanishi, K. (2003). Superantigenic stimulation of bovine T cells by Streptococcus dysgalactiae-derived mitogen (SDM).

| J. Tokyo Women’s Medical University 73:24-33 

学術論文

Miyahira, Y., Katae, M., Kobayashi, S., Takeuchi, T., Fukuchi, Y., Abe, R., Okumura, K., Yagita, H. and Aoki, T. (2003). Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection.

| Infection and Immunity 71: 3131-3137 

学術論文

Matsumoto, A., Seki, Y., Watanabe, R., Hayashi, K., Johnston, JA., Harada, Y., Abe, R., Yoshimura, A., and Kubo, M. (2003). A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production.

| J. Exp. Med. 197:425-436 

学術論文

Harada, Y., Ohgai, D., Watanabe, R., Okano, K., Koiwai, O., Tanabe, K., Toma, H., Altman, A, and Abe, R. (2003). A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimula

| J. Exp. Med. 197:257-262 

学術論文

Tominaga, N., Ohkusu-Tsukada, K., Udono, H., Abe, R., Matsuyama, T., and Yui, K., (2003). Development of Th1 and not Th2 immune responses in mice lacking interferon regulatory factor-4.

| Int. Immunology 15:1-10 

学術論文

Zhou, X-Y, Yashiro-Ohtani Y., Nakahira, M., Park WR, Abe, R., Hamaoka, T., Naramura, M., Gu, H., and Fujiwara, H. (2002). Molecular mechanisms underlying differential contribution of CD28 vs non-CD28 costimulatory molecules to IL-2 promoter activati

| J. Immunol.,168:3847-3854 

学術論文

Ogawa, S., Nagamatsu, G., Watanabe, M., Watanabe, S., Hayashi, T., Horita, S., Nitta, K., Nihei, H., Tezuka, K., and Abe, R. (2001). Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody o

| J. Immunol. 167:5741-5748 

学術論文

Sano G., Haffalla, J.C.R., Morrot, A., Abe, R., Lafaille J.J. and Zavala, F. (2001). Swift development of protective effector functions in naive CD8+ T cells against malaria liver stages.

| J Exp Med. 16;194(2):173-80 

学術論文

Riley, J.L., Blair, P.J., Musser, J.T., Abe, R., Tezuka, K., Tsuji, T., and June, C.H. (2001). ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement

| J. Immunol. 166:4943-4948 

学術論文

Park, W-R, Park, C-S, Tomura, M., Ahn, H-J, Nakahira, Y., Iwasaki, M., Gao, P., Abe, R., Hamaoka, T., and Fujiwara, H. (2001). CD28 costimulation is required not only to induce IL-12 receptor but also to render Janus kinases/STAT4 responsive to IL-1

| Eur. J. Immunol. 31:1456-1464,  

学術論文

Harada, Y., Tokushima, M., Matsumoto, Y., Ogawa, S., Otsuka, M., Hayashi, K., June, C.H. and Abe, R. (2001). Critical requirement for the membrane-proximal cytosolic tyroinse residue for CD28-mediated costimulation in vivo.

| J. Immunol. 166:3797-3803 

学術論文

Harada, Y., Tanabe, E., Watanabe, R., Weiss, B.D., Matsumoto, A., Ariga, H., Koiwai, O.,Fukui, Y., Kubo, M., June, C.H., and Abe, R. (2001). Novel role of Phosphatidylinositol 3-Kinase in CD28-mediated costimulation.

| J. Biol. Chem. 276:9003-9008 

学術論文

Ogawa S., Nitta, K., Hara, Y., Horita, S., Nihei, H., and Abe, R. (2000). CD28 knockout mice as a useful clue to examine the pathogenesis of chronic graft-versus-host reaction (GVHR).

| Kidney International 58:2215-2220 

学術論文

Blair, P.J., Riley, J.L., Harlan, D.M., Abe, R., Tadaki, D.K., Hoffmann, S.C., White, L., Francomano, T., Perfetto, S.J., Kirk A.D., and June, C.H. (2000). CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in s

| J. Exp. Med. 191:651-60 

学術論文

Yashiro-Ohtani, Y., Zhou, X.-Y., Toyo-oka, K. , Tai, X-G, Park, C-S., Hamaoka, T., Abe, R., Miyake, K., and Fujiwara, H. (2000). Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of T c

| J. Immunol. 164:1251-1259 

学術論文

Nakaseko, C., Miyatake, S., Iida, T., Abe, R., and Saito, T (1999). CTLA-4 engagement delivers inhibitory signal upon T cell activation in the absence of its tyrosine motif in the cytoplasmic tail.

| J. Exp. Med. 190:765-774 

学術論文

Kubo, M., Yamashita, M., Abe, R., Tada, T. Okumura, K., Ransom, J.T., and Nakayama, T. (1999). CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiation.

| J. Immunol. 163:2432-2442 

学術論文

Ashe, J.M., Wiest, D.L., Abe, R., and Singer, A. (1999). ZAP-70 protein promotes tyrosine phosphorylation of TCR signaling motifs (ITAMs) in immature CD4+8+ thymocytes with limiting p56lck.

| J. Exp. Med. 189:1163-1167 

学術論文

Abe, R., Ogawa, S., and Tokushima, M. (1998). Role of CD28-mediated costimulatory signals in the development of chromic graft versus host reaction.

| 10th International Congress of Immunology. Talwar, G.P., Nath, I., Ganguly, N.K., Rao, K.V.S.(eds). Monduzzi Editore, Bologna, Italy, p891-896 

学術論文

Yu, X., Abe, R., and Hodes, R.J. (1998). The role of B7-CD28 co-stimulation in tumor rejection.

| Int. Immunol. 10:791-798 

学術論文

Aoki, N., Inobe, M., Murakami, M., Abe, R. and Iizuka, H. (1998). The functional role of B7 molecules on the induction of thymocyte activation and apoptosis.

| Microbiol. Immunol. 42:555-565 

学術論文

Saito, K., Sakurai, J., Ohata, J., Kohsaka, T., Hashimoto, H., Okumura, K., Abe, R., and Azuma, M. (1998). Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute Graft-Versus-Host disease induced by allogeneic T cells lacking CD28.

| J. Immunol. 160:4225-4231 

学術論文

Yasiro Y., Tai, X.G., Toyo-oka, K. Park, C.S., Abe, R., Hamaoka, T. Kobayashi, M. Neben, S., and Fujiwara, H. (1998). A fundamental difference in the capacity to induce proliferation of Naïve T cells between CD28 and other co-stimulatory molecules.

| Eur. J. Immunol. 28:926-937 

学術論文

Kozono, Y., Abe, R., Kozono, H., Kelly, R.G., Azuma, T., and Holers, V.M. (1998). Cross-linking CD21/35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells.

| J. Immunol. 160:1565-1572 

学術論文

Toyo-oka, K., Tai, X.G., Yashiro, Y., Ahn, H.J., Abe, R., Hamaoka, T., Kobayashi, M., Neben, S., and Fujiwara, H. (1997). Synergy between CD28 and CD9 cotimulation for naïve T-cell activation.

| Immunol. Lett. 58:19-23 

学術論文

Punt, J.A., Harvan, W., Abe,R., Sarin, A., and Singer, A. (1997). T cell receptor(TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selectio

| J. Exp. Med. 186:1911-1922 

学術論文

Tai, X-G, Toyooka, K., Yashiro, Y., Abe, R., Park, C-S., Hamaoka, T., Kobayashi, M., Neben, S., and Fujiwara, H. (1997). CD9-mediated costimulation of T cell receptor-triggered naive T cells leads to activation followed by apoptosis.

| J.Immunol. 159:3799-3807 

学術論文

Wiest, D.L., Ashe, J.M., Howcroft, K., Lee, H-M, Kemper, D.M., Negishi, I., Singer, D., Singer, A., and Abe, R. (1997). A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

| Immunity 6:663-671 

学術論文

Gause, W.C., Chen, S.J., Greenwald, R., Halvorson, M., Lu, P., Zhou, X.. Morris, S.C., Lee, K., June, C., Finkelman, F.D., Urban, J.F., and Abe, R. (1997). CD28-dependence of T cell differentiation to IL-4 production varies with the particular type2

| J. Immunol. 158:4082-4087 

学術論文

Tashiro, M., Kawakami, Y., Abe, R., Han, W., Hata, D., Sugie, K., Yao, Libo, and Kawakami, T. (1997).Increased secretion of tumor nectosis factor by co-stimulation of mast cells via CD28 and FceRI.

| J. Immunol. 158:2382-2389 

学術論文

Perrin, P.J., Davis, T.A., Smoot, D.S., Abe, R., June, C.H., and Lee, K.P. (1997). Mitogenic stimulation of T cells reveals differing contributions for B7-1 (CD80) and B7-2 (CD86) costimulation.

| Immunology 90:534-542 

学術論文

Hugin A.W., Tang, Y, Vacchio, M.S., Hodes, R.J., Morawetz, R.A., Giese, N.A., Abe, R., Kim, W., Chattopadhyay, S.K., Scherer, M.T., Moore, M.W., Fredrickson, T.N., Amory, J.K., Kulkarni, A., Hartley, J.W., Morse, H.C. III. (1995). Is a Superantigen

| Viral Surperantigens. Tomonari, K. (eds.) CRC Press Inc., FL. USA. p207-218 

学術論文

Saha, B., Jaklic, B., Harlan, D.M., Gray, G.S., June, C.H. and Abe, R. (1996). Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig.

| J. Immunol. 157:3869-3875 

学術論文

King,C.L., Xianli,J., June,C.H., Abe, R., and Lee,K.P. (1996). CD28-deficient mice generate an impaired Th2 response to shistosoma mansoni infection.

| Eur. J. Immunol. 26:2448-2455 

学術論文

Perrin, P.J., Scott, D., Davis T.A., Gray, G.S., Doggett, M.J., Abe, R., June, C.H., and Racke, M.K., (1996). Opposing Effects of CTLA4Ig and Anti-CD80 (B7-1) plus Anti-CD86 (B7-2) on Experimental Allergic Encephalomyelitis.

| J. Neuroimmunol. 65:31-39 

学術論文

Tai, X.G., Yashiro Y., Abe, R., Toyooka, K., Wood, C.R., Morris, J.,Long, A., Ono, S., Kobayashi, M., Hamaoka, T.,Neben, S., and Fujiwara H. (1996). A role for CD9 molecules in T cell activation

| J.Exp.Med. 184:753-758, 

学術論文

Murakami, M., Takahashi, Y., Isashi, Y., Kon, S., Jia, W-Y., Inobe, M., Abe, R. and Uede, T. (1996). Identification and characterization of an alternative cytotoxic T lymphocyte-associated protein 4 binding molecule on B cells.

| Proc.Natl.Acad.Sci.USA 93:7838-7842 

学術論文

Wiest, D.L., Ashe, J.M., Abe, R., Bolen, J.B., and Singer, A. (1996). TCR activation of ZAP70 is impaired in CD4+8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

| Immunity 4:495-504 

学術論文

Inobe, M., Aoki, N, Linsley, P.S., Ledbetter, J.A., Abe, R., Murakami, M, and Uede, T. (1996). The role of MB7-2 molecule, an alternatively spliced from of murine B7-1, on T cell activation.

| J. Immunl. 157:582-588 

学術論文

Saha, B, Harlan, D.M., Lee, K.P., June, C.H.,and Abe, R. (1996). Protection against lethal toxic shock by targeted disruption of the CD28 gene.

| J.Exp.Med. 183:2675-2680 

学術論文

Palmer, L.D., Saha, B., Hodes, R.J., and Abe, R. (1996) . The role of CD28 costimulation in immune-mediated responses agaist MMTV.

| J. Immunol. 156:2112-2118 

学術論文

Toyooka, K., Maruo, S., Iwahori, T., Yamamoto, N., Tai, Xu-Guang, Abe, R., Takahama, Y., Murakami, J., Uede, T., Hamaoka, T., and Fujiwara, H. (1996). CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells b

| Int. Immunology 8:159-169 

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Racke, M.K., Scott, D.E., Quigley, L., Gray, G.S., Abe, R., June, C.H. and Perrin, P.J. (1995). Distinct Roles for B7-1 (CD-80) and B7-2 (CD-86) in the Initiation of Experimental Allergic Encephalomyelitis.

| J. Clinical Investigation 96:2195-2203 

学術論文

Hakim, F.T., Cepeda, R., Gray, G, June, C.H., and Abe, R. (1995). Acute Graft-Versus-Host Reaction Can Be Aborted by Blockeade of Costimulatory Molecules.

| J. Immunol. 155:1757-1766 

学術論文

Harlan, D.M., Barnett, M.A., Abe, R., Pechhold, K. Patterson, M.B., Gray G.S., and June, C.H. (1995). Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice.

| DIABETES 44:816-23 

学術論文

June, C.H., Abe, R., and Rabinovitch, P.S. (1995). Measurement of Interacellular Ions by Flow Cytometry. Current Protocal in Immunology.

| Volue 1, PP.5.5.1.-5.5.21 

学術論文

Harlan, D.M., Abe, R., Lee, K.P., and June C.J. (1995). Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion.

| Clinical Immunology and Immunopathology 75:99-111 

学術論文

Perrin, J.P, Scott, D., Quigley, L., Albert, P.S., Feder, O., Gray, G.S., Abe, R., June, C.H. and Racke, M.K. (1995). Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis.

| J. Immunol. 154:1481-1490 

学術論文

Abe, R., Vandenberghe, P, Craighead, N., and June, C.H. (1995). Distinct Signal Transduction in Mouse CD4+ and CD8+ splenic T cells after CD28 ligation.

| J. Immunol. 154:985-997 

学術論文

Harlan, D.M., Hengartner, H., Huang, M.L., Kang, Y-H, Abe, R., Moreadith, R.W., Pircher, H., Gray, G.S., Ohashi, P.S., Freeman, G., Nadler, L.M., June, C.H., and Aichele, P. (1994). Mice expressing both B7-1 and viral glycoprotein on pancreatic beta

| Proc. Natl. Acad. Sci. USA. 91:3137-3141 

学術論文

Ishida, Y., Chused, T.M., Murakami, S. and Abe, R. (1994). Antigen-specific cell conjugate formation and long-lasting calcium responses in recognition of Mls cellular supreantigen by cloned murine T lymphocytes.

| Cellular Immunol. 155:414-27 

学術論文

Yui, K., Ishida, Y, Chused, T. and Abe, R. (1993). Down modulation of activation potential and complete anergy are two mechanisms involved in T cell unresponsiveness.

| J. Immunol. 151:6062-6075 

学術論文

Abe, R., Kozak, C.A., Foo Phillips, M., Roberts, J., and Principato, M.A. (1993). Involvement of multiple factors in the clonal deletion of self- reactive T cells.

| Cellular Immunology 151:425-436 

学術論文

Hodes, R.J., Abe, R. and R. Callahan. (1993). T cell receptor Vß repertoire expression in the absence of endogenous mouse mammary tumor provirus.

| Immunogenetics 37:309-311 

学術論文

Foo Phillips, M., Kozak, C., Principato, M.A. and Abe, R. (1992). Characterization of a Mlsf system. II. Identification of MMTV proviruses involved in the clonal deletion of self Mlsf reactive T cells.

| J. Immunol. 149:3440-3447 

学術論文

Abe, R., Foo Phillips, Granger, L. and Kanagawa, O. (1992). Characterization of a Mlsf system. I. A novel "polymorphism" of endogenous superantigens.

| J. Immunol. 149.3429-3439 

学術論文

Hodes, R.J. and Abe, R. (1992). Mouse endogenous superantigens: Mls and Mls like determinants encoded by mouse retroviruses.

| Current Protocal in Immunology A.1.21 

学術論文

Roberts, J.L., Abe, R., Shores, E.W., and Singer A. (1992). Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or x linked immunodeficiency (xid) deffect.

| J. Immunol. 149:1577-1582 

学術論文

Hodes, R.J. and Abe, R. (1992). T cell recognition of Mls like superantigens: Analysis of TCR requirements, superantigenic ligands, and signal transduction.

| Seminor in Immunology 4:319-327 

学術論文

Abe, R., Ishida, Y., Yui, K., Katsumata, M. and Chused, T.M. (1992). T cell receptor-mediated recognition of self-ligand induces signaling in immature thymocytes before negative selection.

| J. Exp. Med. 176:459-468 

学術論文

Abe, R., Kanagawa, O., Sheard, M.A., Malissen, B., and Foo Phillips, M. (1991). Characterization of a new Mls system I. cluster of self antigens recognized by "I E reactive" TCR Vßs, Vß5, Vß11, and Vß12.

| J. Immunol. 147:739 

学術論文

Murakami, S., Miyake, K., Abe, R., Kincade, P.W. and Hodes, R.J. (1991). Characterization of autoantibody secreting B cells in mice undergoing stimulatory (chronic) GVH reactions: Identification of a CD44hi population that binds specificcally to hyal

| J. Immunol. 146:1422 

学術論文

Abe, R., Foo Phillips, M. and Hodes, R.J. (1991). Genetic analysis of the Mls system: Formal Mls typing of the commonly used inbred strains.

| Immunogenetics 33:62 

学術論文

Abe, R. (1990). "Mls"

| Encyclopedia of Immunology Roitt, I.M. and Delves, R.J (eds.). Saunders Scientific Publications, p.1082 

学術論文

Abe, R., Foo Philips, M. and Hodes, R.J. (1989). Analysis of Mlsc genetics:A novel instance of genetic redundancy

| J. Exp. Med. 170:1059 

学術論文

Abe, R. and Hodes, R.J. (1989). T cell recognition of minor lymphocyte stimulating (Mls) gene products.

| Ann. Rev. Immunol. 7:683 

学術論文

Abe, R. and Hodes, R.J. (1989). Properties of the Mls system: A revised formulation of Mls genetics and an analysis of T cell recognition of Mls determinants.

| Immunol. Rev. 107:5 

学術論文

Seldin, M.F., Abe, R., Steinberg, A.D., Hodes, R.J. and Morse, J.C. III. (1988). Genetic relationships of Mlsa among polymorphic loci on distal mouse chromosome 1.

| J. Immunogenetics 15:59 

学術論文

Abe, R. and Hodes, R.J. (1988). A reappraisal of Mls genetics.

| J. Immunogenetics 15:11 

学術論文

Abe, R. and Hodes, R.J. (1988). Mls determinants recognized by T cells.

| J. Immunogenetics 15:5 

学術論文

Abe, R., Vacchio, M.S., Fox. B., and Hodes, R.J. (1988). Preferential expression of the T cell receptor Vß gene by Mlsc reactive T cells.

| Nature 335:827 

学術論文

Abe, R. and Hodes, R.J. (1988). The expression of Mlsc determinants on Mlsa, Mlsb, and Mlsx prototypic strains.

| Immunogenetics 28:221 

学術論文

Abe, R. and Hodes, R.J. (1988). The Mls system: non MHC genes that encode strong T cell stimulatory determinants.

| Immunology Today 9:230 

学術論文

Abe, R. and Hodes, R.J. (1988). T cell recognition of Mlsc: I. Influence of MHC gene products in Mlsc specific T cell recognition

| J. Immunol. 140:4132 

学術論文

Abe, R. and Hodes, R.J. (1988). Genetic analysis of serologically undefined determinants: A T cell "clonological" analysis of the Mls system.

| Current Topics in Microbiology and Immunology 137:177. 

学術論文

Abe, R., Ryan, J.J., and Hodes, R.J. (1987). Mls is not a single gene, allelic system: Different stimulatory Mls determinants are the products of atleast two non allelic, unlinked genes.

| J. Exp. Med. 166:1150. 

学術論文

Tada, T., Uracz, W. and Abe, R. (1987). Are there unique I region controlled determinants on T cells?

| Paradoxes in Immunology Hoffmann, G.W., Levy, J.G., and Nepom, G.T. (eds.). Boca Raton, Florida, CRC Press, Inc. pp. 253-270 

学術論文

Tsuji, M., Yagi, J., Abe, R., Asano, Y. and Tada, T. (1987). Shared idiotopes between anti class II monoclonal antibodies and major histocompatibility complex recognition site of T cells.

| Eur. J. Immunol. 17:675. 

学術論文

Sano, K., Fujisawa, I., Abe, R., Asano, Y. and Tada, T. (1987). MHC restricted minimal regulatory circuit initiated by a class II autoreactive T cell clone

| J. Exp. Med. 165:1284 

学術論文

Abe, R., Ryan, J.J., and Hodes, R.J. (1987). Clonal analysis of the Mls system. A reappraisal of polymorphism and Allelism among Mlsa, Mlsc, and Mlsd.

| J. Exp. Med. 165:1113 

学術論文

Abe, R., Yagi, J., Asano, Y. and Tada, T. (1987). Epitopes associated with the MHC restriction site of T cells. I. Selective expression of Iat epitopes on H 2 restricted helper T cells.

| J.Immunol. 138:2964 

学術論文

Abe. R., Ryan, J.J., Finkelman, F.D., and Hodes, R.J. (1987). T cell recognition of Mls: T cell clones demonstrate polymorphism between Mlsa, Mlsc and Mlsd.

| J. Immunol. 138:373 

学術論文

Yagi, J., Nonaka, M., Abe, R. and Tada, T. (1986). Ir gene expression on T cells: Effects of monoclonal antibodies directed against I region Controlled determinants on T cells.

| Eur. J. Immunol. 16:497. 

学術論文

Tada, T., Abe, R., Yagi, J., Uracz, W., Fujisawa, I. and Asano, Y. (1985). Immunoregulatory molecules and circuits revisited with monoclonal antibodies.

| Monoclonal Antibodies '84: Biological and Clinical Application. Pinchera, A., Doria, G., Dammacco, F. and Bargellesi, A. (eds.). Editrice Kurtis, Mirano. pp.87. 

学術論文

Tada, T., Abe, R., Yagi, J., Uracz, W., Fujisawa, I., Miyatani, S., Kumagai, Y., Asano, Y. and Okumura, K. (1985). Antigen and self recognition structures on antigen specific T cell factors.

| Immunopharmacology. Miescher, P.A., Bolis, L. and Ghione, M. (eds.). Raven Press, New York. pp.13 

学術論文

Uracz, W., Asano, Y., Abe, R., and Tada, T. (1985). I-J epitopes are adaptively acquired by T cells differentiated in the chimeric condition.

| Nature 316:741 

学術論文

Tada, T., Uracz, W., Abe, R., and Asano, Y. (1985). I J as an inducible T cell receptor for self.

| Immunol. Rev. 83:105. 

学術論文

Uracz, W., Abe, R., and Tada, T. (1985). Involvement of I J epitopes in the self and allo recognition sites of T cells: Blocking of syngeneic and allogeneic mixed lymphocyte reaction-responder cells by monoclonal anti I J antibodies.

| Proc. Natl. Acad. Sci. USA. 82:2905. 

学術論文

Kurata, A., Yamauchi, K., Watanabe, T., Nonaka, M., Abe, R., Okumura, K., and Tada, T. (1984). Is there multiplicity in I J subregion products?

| J. Mol. Cell. Immunol. 1:267. 

学術論文

Tada, T., Abe, R., Uracz. W., Yagi, J., Miyatani, S., Kumagai, Y., Ochi, A., Fujisawa, I. (1984). Synaptic structures in the Immunological circuit. In: Regulation of the Immune System.

| Cantor, H., Chess, L. and Sercarz, E. E. (eds.). Alan R. Liss, Inc., New York. pp.663 

学術論文

Tada, T , Abe, R., Miyatani, S., Yagi, J., Uracz, W. and Ochi, A. (1984). Self recognition by T cells: Analysis with monoclonal antibodies that block the MHC restricted cell interactions.

| Immunogenetics. Its Application to Clinical Medicine. Sasazuki, T. and Tada, T. (eds.). Academic Press, Tokyo. pp.171. 

学術論文

Abe, R., Karasuyama, H., Yagi, J. and Tada, T. (1984). Regulation of allotype linked NPb idiotype by an idiotype positive soluble factor derived from a T cell hybridoma coupling of the circuit regulation to the network concept.

| Int. Arch. Allergy App. Immunol. 74:289-296. 

学術論文

Ikezawa, Z., Baxevanis, C. N., Nonaka, M., Abe, R., Tada, T., Nagy, Z.A. and Klein, J. (1983). Monoclonal suppressor factor specific for lactate dehydrogenase B. I. Mechanism of interaction between the factor and its target cells.

| J. Exp. Med. 157:1855-1866. 

学術論文

Ikezawa, Z., Nonaka, M., Abe, R., Tada, T., Nagy, Z. A. and Klein, J. (1983). Induction of T cell responses in nonresponder mice by abolishing suppression with monoclonal antibodies recognizing I region controlled T cell specific determinants.

| J. Immunol. 131:1646-1649. 

学術論文

Tada, T., Hiramatsu, K., Nonaka, M., Miyatani, S. and Abe, R. (1983). T-T cell interactions in the regulation of the antibody response: The role of I region products on T cells. 

| Advances in Immunopharmacolog. Oxford and New York, Pergamon Press. pp. 301-306 

学術論文

Tada, T., Ochi, A., Miyatani, S., Abe, R., Yagi, J. and Yamauchi, K. (1983). Epitope organizations of I region products associated with antigen specific augmenting and suppressor T celll factors.

1983年 | Ir Genes, Past, Present and Future. Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D. and Shreffler, D.C. (eds.). Clifton, Humana Press. pp.599 

学術論文

Tada, T., Suzuki, G., Abe, R., Kumagai, Y., Hiramatsu, K, and Miyatani, S. (1983). IgVH and MHC restricted regulatory circuit in the immune response.

1983年 | Immunoregulation. Fabris, N., Garaci, E., Hadden, J. and Mitchson, N. Y.(eds.).New York, Academic Press, pp. 1  

学術論文

Tada, T., Okumura, K., Hayakawa, K., Suzuki, G., Abe, R. and Kumagai, (1981). Immunological circuitry governed by MHC and VH gene products.

| Immunoglobulin Idiotypes. Janeway, C., Sercarz, E.E. and Wigzell, H. (eds.). New York, Academic Press, pp. 563