帝京大学
鈴木 利宙

鈴木 利宙 講師

所属キャンパス板橋キャンパス

研究所・センター 医療共通教育研究センター

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経歴・所属学会・専門分野・研究テーマ

経歴

【経歴】──────────────────────────────

2021年04月

帝京大学医学部薬理学講座助教

所属学会

日本免疫学会

日本癌学会

教育方法・職務上の実績

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著書・論文

学術論文

Satoshi Okubo, Toshihiro Suzuki, Masayoshi Hioki, Yasuhiro Shimizu, Hirochika Toyama, Soichiro Morinaga, Naoto Gotohda, Katsuhiko Uesaka, Genichiro Ishii, Shinichiro Takahashi, Motohiro Kojima

The immunological impact of preoperative chemoradiotherapy on the tumor microenvironment of pancreatic cancer.

2021年05月01日 | Cancer science  

学術論文

Keigo Chida, Akihito Kawazoe, Masahito Kawazu, Toshihiro Suzuki, Yoshiaki Nakamura, Tetsuya Nakatsura, Takeshi Kuwata, Toshihide Ueno, Yasutoshi Kuboki, Daisuke Kotani, Takashi Kojima, Hiroya Taniguchi, Hiroyuki Mano, Masafumi Ikeda, Kohei Shitara, I

A low tumor mutational burden and PTEN mutations are predictors of a negative response to PD-1 blockade in MSI-H/ dMMR gastrointestinal tumors.

2021年04月29日 | Clinical cancer research : an official journal of the American Association for Cancer Research  

学術論文

Hiroyasu Aoki, Satoshi Ueha, Shigeyuki Shichino, Haru Ogiwara, Kohei Shitara, Manami Shimomura, Toshihiro Suzuki, Tetsuya Nakatsura, Makiko Yamashita, Shigehisa Kitano, Sakiko Kuroda, Masashi Wakabayashi, Makoto Kurachi, Satoru Ito, Toshihiko Doi, Ko

Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer.

2021年03月05日 | Cancer immunology research  

学術論文

Ryo Morisue, Motohiro Kojima, Toshihiro Suzuki, Tetsuya Nakatsura, Hidenori Ojima, Reiko Watanabe, Motokazu Sugimoto, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi, Genichiro Ishii, Naoto Gotohda, Toshiyoshi Fujiwara, Atsushi Ochiai

Sarcomatoid hepatocellular carcinoma is distinct from ordinary hepatocellular carcinoma: Clinicopathologic, transcriptomic and immunologic analyses.

2021年03月04日 | International journal of cancer  

学術論文

Miho Oka, Liu Xu, Toshihiro Suzuki, Toshiaki Yoshikawa, Hiromi Sakamoto, Hayato Uemura, Akiyasu C Yoshizawa, Yutaka Suzuki, Tetsuya Nakatsura, Yasushi Ishihama, Ayako Suzuki, Masahide Seki

Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer.

2021年01月04日 | Genome biology 22 1 9-9 

学術論文

Ken Imaizumi, Toshihiro Suzuki, Motohiro Kojima, Manami Shimomura, Naoki Sakuyama, Yuichiro Tsukada, Takeshi Sasaki, Yuji Nishizawa, Akinobu Taketomi, Masaaki Ito, Tetsuya Nakatsura

Ki67 expression and localization of T cells after neoadjuvant therapies as reliable predictive markers in rectal cancer.

2020年01月 | Cancer science 111 1 23-35 

学術論文

Yu Gong, Toshihiro Suzuki, Haruo Kozono, Masato Kubo, Naoko Nakano

Tumor-infiltrating CD62L+PD-1-CD8 T cells retain proliferative potential via Bcl6 expression and replenish effector T cells within the tumor.

2020年 | PloS one 15 8 e0237646 

学術論文

Kohei Shitara, Satoshi Ueha, Shigeyuki Shichino, Hiroyasu Aoki, Haru Ogiwara, Tetsuya Nakatsura, Toshihiro Suzuki, Manami Shimomura, Toshiaki Yoshikawa, Kayoko Shoda, Shigehisa Kitano, Makiko Yamashita, Takayuki Nakayama, Akihiro Sato, Sakiko Kuroda,

First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors.

2019年07月24日 | Journal for immunotherapy of cancer 7 1 195-195 

学術論文

Marina Okada, Yoshitaka Tada, Tomohisa Seki, Shugo Tohyama, Jun Fujita, Toshihiro Suzuki, Manami Shimomura, Kazuya Ofuji, Yoshikazu Kishino, Kazuaki Nakajima, Sho Tanosaki, Shota Someya, Hideaki Kanazawa, Satoru Senju, Tetsuya Nakatsura, Keiichi Fuku

Selective elimination of undifferentiated human pluripotent stem cells using pluripotent state-specific immunogenic antigen Glypican-3.

2019年04月09日 | Biochemical and biophysical research communications 511 3 711-717 

学術論文

Akazawa Y, Mizuno S, Fujinami N, Suzuki T, Yoshioka Y, Ochiya T, Nakamoto Y, Nakatsura T

Usefulness of serum microRNA as a predictive marker of recurrence and prognosis in biliary tract cancer after radical surgery.

2019年04月 | Scientific reports 9 1 5925 

学術論文

Prospects for immunotherapy as a novel therapeutic strategy against hepatocellular carcinoma.

2019年03月 | World J Metaanal. 7 3 80-95 

学術論文

Shimizu Y, Suzuki T, Yoshikawa T, Endo I, Nakatsura T

Next-Generation Cancer Immunotherapy Targeting Glypican-3.

2019年 | Frontiers in oncology 9 248 

学術論文

Takahashi D, Kojima M, Suzuki T, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, Gotohda N, Ikeda M, Nakatsura T, Ochiai A, Nagino M

Profiling the Tumour Immune Microenvironment in Pancreatic Neuroendocrine Neoplasms with Multispectral Imaging Indicates Distinct Subpopulation Characteristics Concordant with WHO 2017 Classification.

2018年09月 | Scientific reports 8 1 13166 

学術論文

Yasuhiro Shimizu, Toshihiro Suzuki, Toshiaki Yoshikawa, Nobuhiro Tsuchiya, Yu Sawada, Itaru Endo, Tetsuya Nakatsura

Cancer immunotherapy-targeted glypican-3 or neoantigens

2018年03月01日 | Blackwell Publishing Ltd Cancer Science 109 3 531-541 

学術論文

Yu Akazawa, Toshihiro Suzuki, Tetsuya Nakatsura

Enhancement of cytotoxic T lymphocytes (CTLs) infiltration into the cancer tissues

2018年02月01日 | Japanese Journal of Cancer and Chemotherapy Publishers Inc. Japanese Journal of Cancer and Chemotherapy 45 2 227-231 

学術論文

清水康弘, 鈴木利宙, 遠藤格, 中面哲也

がん免疫療法の歴史と今後の課題

2018年 | 最新医学 73 2 174-181 

学術論文

Babita Shashni, Shinya Ariyasu, Reisa Takeda, Toshihiro Suzuki, Shota Shiina, Kazunori Akimoto, Takuto Maeda, Naoyuki Aikawa, Ryo Abe, Tomohiro Osaki, Norihiko Itoh, Shin Aoki

Size-based differentiation of cancer and normal cells by a particle size analyzer assisted by a cell-recognition PC software

2018年 | Pharmaceutical Society of Japan Biological and Pharmaceutical Bulletin 41 4 487-503 

学術論文

Keisuke Tanamachi, Keisuke Nishino, Natsuki Mori, Toshihiro Suzuki, Sei-ichi Tanuma, Ryo Abe, Mitsutoshi Tsukimoto

Radiosensitizing Effect of P2X7 Receptor Antagonist on Melanoma in Vitro and in Vivo

2017年06月 | PHARMACEUTICAL SOC JAPAN BIOLOGICAL & PHARMACEUTICAL BULLETIN 40 6 878-887 

学術論文

鈴木 利宙, 中面 哲也

「特集」躍進するがん免疫療法 ネオアンチゲンとそれを標的としたがんワクチン療法

2017年 | 日本薬学会会誌「ファルマシア」 53 1 15-19 

学術論文

鈴木利宙, 安部良

IL-7の抗腫瘍応答における功罪 –抗腫瘍免疫応答の増強による抗腫瘍効果と炎症誘導を介した腫瘍形成の促進-

2017年 | 医学のあゆみ 261 11 1095-1101 

学術論文

Toshihiro Suzuki, Hidehiro Kishimoto, Ryo Abe

Requirement of interleukin 7 signaling for anti-tumor immune response under lymphopenic conditions in a murine lung carcinoma model

2016年03月 | SPRINGER CANCER IMMUNOLOGY IMMUNOTHERAPY 65 3 341-354 

学術論文

Hiromasa Okano, Tomoki Konishi, Toshihiro Suzuki, Takahiro Suzuki, Shinya Ariyasu, Shin Aoki, Ryo Abe, Masanori Hayase

Enrichment of circulating tumor cells in tumor-bearing mouse blood by a deterministic lateral displacement microfluidic device

2015年06月 | SPRINGER BIOMEDICAL MICRODEVICES 17 3 9964 

学術論文

Yosuke Hisamatsu, Ai Shibuya, Nozomi Suzuki, Toshihiro Suzuki, Ryo Abe, Shin Aoki

Design and Synthesis of Amphiphilic and Luminescent Tris-Cyclometalated Iridium(III) Complexes Containing Cationic Peptides as Inducers and Detectors of Cell Death via a Calcium-Dependent Pathway

2015年05月 | AMER CHEMICAL SOC BIOCONJUGATE CHEMISTRY 26 5 857-879 

学術論文

Koichi Kutsuzawa, Toshihiro Suzuki, Hidehiro Kishimoto, Akiichi Murakami, Takachika Azuma, Ryo Abe, Hidenori Otsuka

Highly robust protein production by co-culture of CHO spheroids layered on feeder cells in serum-free medium

2014年04月 | SPRINGER COLLOID AND POLYMER SCIENCE 292 4 839-848 

学術論文

Iida, S, Suzuki, T, Tanabe, K, A. Valujskikh, R. L. Fairchild, Abe, R

Transient lymphopenia breaks costimulatory blockade-based peripheral tolerance and initiates cardiac allograft rejection

2013年09月 | AMERICAN JOURNAL OF TRANSPLANTATION 13 9 2268-79 

学術論文

Koichi Kutsuzawa, Chihiro Takahashi, Ryohei Sato, Toshihiro Suzuki, Hidehiro Kishimoto, Akiichi Murakami, Takachika Azuma, Ryo Abe, Hidenori Otsuka

Multiarray Formation of CHO Spheroids Cocultured with Feeder Cells for Highly Efficient Protein Production in Serum-Free Medium

2013年01月 | AMER SCIENTIFIC PUBLISHERS JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13 1 229-235 

学術論文

Transient lymphopenia breaks costimulatory blockade-based peripheral tolerance and initiates cardiac allograft rejection

2013年 | A. J. Transplantation 20 1-12 

学術論文

Shinsuke Moromizato, Yosuke Hisamatsu, Toshihiro Suzuki, Yasuki Matsuo, Ryo Abe, Shin Aoki

Design and Synthesis of a Luminescent Cyclometalated Iridium(III) Complex Having N,N-Diethylamino Group that Stains Acidic Intracellular Organelles and Induces Cell Death by Photoirradiation

2012年12月 | AMER CHEMICAL SOC INORGANIC CHEMISTRY 51 23 12697-12706 

学術論文

Shinya Ariyasu, Kengo Hanaya, Eita Watanabe, Toshihiro Suzuki, Kazutaka Horie, Masanori Hayase, Ryo Abe, Shin Aoki

Selective Capture and Collection of Live Target Cells Using a Photoreactive Silicon Wafer Device Modified with Antibodies via a Photocleavable Linker

2012年09月 | AMER CHEMICAL SOC LANGMUIR 28 36 13118-13126 

学術論文

Shoichi Iida, Kazuya Omoto, Izumi Kanemitsu, Kiyoshi Setoguchi, Hideki Ishida, Kazunari Tanabe, Toshihiro Suzuki, Yasuyuki Tashiro, Hidehiro Kishimoto, Ryo Abe

Interleukin-6 Receptor Signaling Disruption Prevents Cardiac Allograft Deterioration in Mice

2012年08月 | BASKENT UNIV EXPERIMENTAL AND CLINICAL TRANSPLANTATION 10 4 375-385 

学術論文

Masanori Kitamura, Toshihiro Suzuki, Ryo Abe, Takeru Ueno, Shin Aoki

B-11 NMR Sensing of d-Block Metal Ions in Vitro and in Cells Based on the Carbon-Boron Bond Cleavage of Phenylboronic Acid-Pendant Cyclen (Cyclen=1,4,7,10-Tetraazacyclododecane)

2011年11月 | AMER CHEMICAL SOC INORGANIC CHEMISTRY 50 22 11568-11580 

学術論文

Tomoyoshi Yamano, Sho Watanabe, Hiroyuki Hasegawa, Toshihiro Suzuki, Ryo Abe, Hideaki Tahara, Takeshi Nitta, Naozumi Ishimaru, Jonathan Sprent, Hidehiro Kishimoto

Ex vivo-expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin grafts

2011年03月 | AMER SOC HEMATOLOGY BLOOD 117 9 2640-2648 

学術論文

Kiyoshi Setoguchi, Hidehiro Kishimoto, Sakiko Kobayashi, Hiroaki Shimmura, Hideki Ishida, Daisuke Toki, Toshihiro Suzuki, Kazunobu Ohnuki, Yoshiki Tate, Shigeru Fujioka, Ryo Abe, Kazunari Tanabe

Potential role of host effector memory CD8(+) T cells in marrow rejection after mixed chimerism induction in cynomolgus monkeys

2010年08月 | ELSEVIER SCIENCE BV TRANSPLANT IMMUNOLOGY 23 4 194-203 

学術論文

Tetsuya Saito, Takuya Takayama, Tadashi Osaki, Shigenori Nagai, Toshihiro Suzuki, Marimo Sato, Hiroyuki Kuwano, Hideaki Tahara

Combined mobilization and stimulation of tumor-infiltrating dendritic cells and natural killer cells with Flt3 ligand and IL-18 in vivo induces systemic antitumor immunity

2008年10月 | WILEY-BLACKWELL CANCER SCIENCE 99 10 2028-2036 

学術論文

鈴木 利宙

Homeostatic Proliferationに伴う抗腫瘍効果誘導におけるCD28シグナルの役割

2008年07月 | 東京大学 124042 

学術論文

Toshihiro Suzuki, Shuhei Ogawa, Kazunari Tanabe, Hideaki Tahara, Ryo Abe, Hidehiro Kishimoto

Induction of antitumor immune response by homeostatic proliferation and CD28 signaling

2008年04月 | AMER ASSOC IMMUNOLOGISTS JOURNAL OF IMMUNOLOGY 180 7 4596-4605 

学術論文

M Sato, T Takayama, H Tanaka, J Konishi, T Suzuki, T Kaiga, H Tahara

Generation of mature dendritic cells fully capable of T helper type 1 polarization using OK-432 combined with prostaglandin E-2

2003年12月 | JAPANESE CANCER ASSOC CANCER SCIENCE 94 12 1091-1098 

学術論文

T Shimizu, K Sato, T Suzuki, K Tachibana, K Takeda

Induction of plasminogen activator inhibitor-2 is associated with suppression of invasive activity in TPA-mediated differentiation of human prostate cancer cells

2003年09月 | ACADEMIC PRESS INC ELSEVIER SCIENCE BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 309 2 267-271 

学術論文

T Suzuki, T Shimizu, K Satoh, R Sugibayashi, K Takeda

Differential expression of genes during TPA-induced differentiation of human prostatic cancer TSU-Pr1 cells

2002年12月 | PROFESSOR D A SPANDIDOS INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 10 6 735-739 

学術論文

R Sugibayashi, Y Kiguchi, T Shimizu, T Suzuki, H Hamada, K Takeda

Up-regulation of p21(WAF1/CIP1) levels leads to growth suppression of prostate cancer cell lines

2002年03月 | INT INST ANTICANCER RESEARCH ANTICANCER RESEARCH 22 2A 713-719 

学術論文

R Sugibayashi, T Shimizu, T Suzuki, N Yamamoto, H Hamada, K Takeda

Upregulation of p21(WAF1/CIP1) leads to morphologic changes and esterase activity in TPA-mediated differentiation of human prostate cancer cell line TSU-Pr1

2001年03月 | NATURE PUBLISHING GROUP ONCOGENE 20 10 1220-1228 

その他

Shoichi Iida, Toshihiro Suzuki, Kazunari Tanabe, Anna Valujskikh, Robert Fairchild, Ryo Abe

TRANSIENT LYMPHOPENIA BREAKS COSTIMULATORY BLOCKADE-BASED TRANSPLANT TOLERANCE AND INITIATES ALLOGRAFT REJECTION

2015年04月 | ELSEVIER SCIENCE INC JOURNAL OF UROLOGY 193 4 E1073-E1073 

その他

Toshihiro Suzuki, Hidehiro Kishimoto, Ryo Abe

Initial IL7R signaling regulate the induction of effector CD8+T cells and subsequent anti-tumor immune response in lymphopenic host

2014年05月 | AMER ASSOC IMMUNOLOGISTS JOURNAL OF IMMUNOLOGY 192  

その他

Hidehiro Kishimoto, Tomoyoshi Yamanol, Toshihiro Suzuki, Ryo Abe

Ex-vivo expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin allografts

2011年04月 | AMER ASSOC IMMUNOLOGISTS JOURNAL OF IMMUNOLOGY 186  

その他

Shoichi Iida, Kazuya Omoto, Kazunari Tanabe, Toshihiro Suzuki, Hidehiro Kishimoto, Ryo Abe

Blockade of Interleukin-6 Receptor Signaling Prevents the Development of Cardiac Allograft Vasculopathy and Propes Allograft Survival in a Mice Model.

2009年 | WILEY-BLACKWELL PUBLISHING, INC AMERICAN JOURNAL OF TRANSPLANTATION 9 400-400 

その他

Toshihiro Suzuki, Hidehiro Kishimoto, Ryo Abe

Anti-tumor immune response induced by homeostatic proliferation and CD28 signaling

2008年04月 | FEDERATION AMER SOC EXP BIOL FASEB JOURNAL 22