帝京大学
滝川 一

滝川 一 教授

Takikawa Hajime

所属キャンパス板橋キャンパス

帝京大学 医療技術学部 スポーツ医療学科 救急救命士コース

消化器は幅広い疾患をカバーしています。やる気のある人、来たれ。

連絡先

電話番号

[]

FAX番号

03-3964-8477

研究室URL

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経歴・所属学会・専門分野・研究テーマ

経歴

【経歴】──────────────────────────────

2018年04月

帝京大学医学部名誉教授

2018年04月

帝京大学医療技術学部学部長

2013年04月

帝京大学医学部医学部長 〜2018年03月

2011年04月

帝京大学医学部内科主任教授 〜2018年03月

1998年04月

帝京大学医学部内科 教授 〜2018年03月

1990年

帝京大学医学部内科 助教授 〜1998年

1987年

帝京大学医学部内科 講師 〜1990年

1984年

UCLA医学部 客員研究員 〜1986年

1980年

東京大学医学部第2内科 医員 〜1984年

【学歴】──────────────────────────────

1977年

東京大学医学部

【委員歴】──────────────────────────────

2016年

日本内科学会 理事、功労会員 〜2018年

2011年

日本消化器病学会 理事、功労会員 〜2017年

2008年

日本肝臓学会 理事

2008年

日本胆道学会 理事、名誉会員 〜2016年

2009年

日本消化器関連学会機構 理事 〜2017年

2002年

日本消化器内視鏡学会 評議員

【受賞】──────────────────────────────

1989年

日本肝臓学会研究奨励賞

1992年

第1回ウルソ賞

所属学会

日本消化器病学会

日本肝臓学会

米国肝臓病学会

日本内科学会

日本消化器内視鏡学会

日本胆道学会

米国消化器病学会

専門分野

内科系臨床医学 消化器内科学

研究テーマ

消化器内科学

教育方法・職務上の実績

職務上の実績

利胆剤

著書・論文

学術論文

Honda A, Tanaka A, Kaneko T, Komori A, Abe M, Inao M, Namisaki T, Hashimoto N, Kawata K, Takahashi A, Ninomiya M, Kang JH, Arakawa M, Yamagiwa S, Joshita S, Umemura T, Sato K, Kaneko A, Kikuchi K, Itakura J, Nomura T, Kakisaka K, Fujii H, Kawada N, T

Bezafibrate improves GLOBE and UK-PBC scores and long-term outcomes in patients with primary biliary cholangitis

2019年12月 | Hepatology 70 2035-2049 

学術論文

Tanaka A, Mori M, Matsumoto K, Ohira H, Tazuma S, Takikawa H

Increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japa

2019年08月 | Hepatol Res 49 881-889 

学術論文

Nakao M, Nakayama N, Uchida Y, Tomiya T, Oketani M, Ido A, Tsubouchi H, Takikawa H, Mochida S

Deteriorated outcome of recent patients with acute liver failure and late-onset hepatic failure caused by infection with hepatitis A virus: A subanalysis of patients seen between 1998 and 2015 and enrolled in nationwide surveys in Japan

2019年08月 | Hepatol Res 49 844-852 

学術論文

Kim JD, Cho EJ, Ahn C, Park SK, Choi JY, Lee HC, Kim DY, Choi MS, Wang HJ, Kim IH, Yeon JE, Seo YS, Tak WY, Kim MY, Lee HJ, Kim YS, Jun DW, Sohn JH, Kwon SY, Park SH, Heo J, Jeong SH, Lee JH, Nakayama N, Mochida S, Ido A, Tsubouchi H, Takikawa H, Sha

A novel model to predict 1-month risk of transplant or death in hepatitis A-related acute liver failure

2019年08月 | Hepatology 70 621-629 

学術論文

Yamaguchi K, Komatsu Y, Satoh T, Uetake H, Yoshino T, Nishida T, Yamazaki N, Takikawa H, Morimoto T, Chosa M, Sunaya T, Hamada Y, Muro K, Sugihara K

Large-scale, prospective observational study of regorafenib in Japanese patients with metastatic colorectal cancer in a real-world clinical practice setting

2019年01月 | Oncologist 24 e450-e457 

学術論文

Kamisawa T, Nakazawa T, Tazuma S, Zen Y, Tanaka A, Ohara H, Muraki T, Inui K, Inoue D, Nishino T, Naitoh I, Itoi T, Notohara K, Kanno A, Kubota K, Hirano K, Isayama H, Shimizu K, Tsuyuguchi T, Shimosegawa T, Kawa S, Chiba T, Okazaki K, Takikawa H, Ki

Clinical practice guidelines for IgG4-related sclerosing cholangitis

2019年01月 | J Hepatobiliary Pancreat Sci 26 9-42 

学術論文

Hitomi Y, Ueno K, Kawai Y, Nishida N, Kojima K, Kawashima M, Aiba Y, Nakamura H, Kouno H, Kouno H, Ohta H, Sugi K, Nikami T, Yamashita T, Katsushima S, Komeda T, Ario K, Naganuma A, Shimada M, Hirashima N, Yoshizawa K, Makita F, Furuta K, Kikuchi M,

POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.

2019年01月 | Sci Rep 9 102 

学術論文

Aiso M, Takikawa H, Tsuji K, Kagawa T, Watanabe M, Tanaka A, Sato K, Sakisaka S, Hiasa Y, Takei Y, Ohira H, Ayada M, Hashimoto E, Kaneko S, Ueno Y, Ohmoto K, Takaki A, Torimura T, Matsuzaki Y, Tajiri K, Yoneda M, Ito T, Kato N, Ikejima K, Mochida S,

An analysis of 307 cases with drug-induced liver injury between 2010 and 2018 in Japan.

2019年01月 | Hepatol Res 49 105-110 

学術論文

Takahashi A, Moriya K, Ohira H, Arinaga-Hino T, Zeniya M, Torimura T, Abe M, Takaki A, Kang JH, Inui A, Fujisawa T, Yoshizawa K, Suzuki Y, Nakamoto N, Koike K, Yoshiji H, Goto A, Tanaka A, Younossi ZM, Takikawa H

Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey.

2018年10月 | PLoS One 13 E0204772 

学術論文

Yagi M, Tanaka A, Namisaki T, Takahashi A, Abe M, Honda A, Matsuzaki Y, Ohira H, Yoshiji H, Takikawa H

Is patient-reported outcome improved by nalfurafine hydrochloride in patients with primary biliary cholangitis and refractory pruritus? A post-marketing, single-arm, prospective study.

2018年09月 | Sci Rep 22 12542 

学術論文

Yagi M, Tanaka A, Abe M, Namisaki T, Yoshiji H, Takahashi A, Ohira H, Komori A, Yamagiwa S, Kikuchi K, Yasunaka T, Takaki A, Ueno Y, Honda A, Matsuzaki Y, Takikawa H

Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis

2018年08月 | Sci Rep 22 12542 

学術論文

Suzuki, Y, Mori T, Yokoyama M, Kim S, Momose H, Matsuki R, Kogure M, Nakazato T, Abe N, Isayama H, Nakazawa T, Notohara K, Tanaka A, Tsuyuguchi T, Tazuma S, Takikawa H, Sugiyama M.

A proposed severity classification system for hepatolithiasis based on an analysis of prognostic factors in a Japanese patient cohort

2018年07月 | J Gastroenterol 53 854-860 

学術論文

Nakao M, Nakayama N, Uchida Y, Tomiya T, Ido A, Sakaida I, Yokosuka O, Takikawa Y, Inoue K, Genda T, Shimizu M, Terai S, Tsubouchi H, Takikawa H, Mochida S

Nationwide survey for acute liver failure and late-onset hepatic failure in Japan

2018年06月 | J Gastroenterol 53 752-769 

学術論文

Mochida S, Nakayama N, Ido A, Inoue K, Genda T, Takikawa Y, Sakaida I, Terai S, Yokosuka O, Shimizu M, Takikawa, H

Proposed Diagnostic Criteria for Acute-On-Chronic Liver Failure in Japan

2018年03月 | Hepatol Res 48 303-312 

学術論文

Nakayama N, Uemura H, Uchida Y, Tomiya T, Ido A, Inoue K, Genda T, Takikawa Y, Sakaida I, Terai S, Yokosuka O, Shimizu M, Takikawa H, Mochida S

A Multicenter Pilot Survey to Clarify the Clinical Features of Patients with Acute-On-Chronic Liver Failure in Japan

2018年03月 | Hepatol Res 48 303-312 

学術論文

Uetake H, Sugihara K, Muto K, Sunaya T, Horiuchi-Yamamoto Y, Takikawa H

Clinical features of regorafenib-induced liver injury in Japanese patients from postmarketing experience

2018年03月 | Clin Colorect Cancer 17 e49-e58 

学術論文

Joshita S, Yoshizawa K, Umemura T, Ohira H, Takahashi A, Harada K, Hiep NC, Tsuneyama K, Kage M, Nakano M, Kang JH, Koike K, Zeniya M, Yasunaka T, Takaki A, Torimura T, Abe M, Yokosuka O, Tanaka A, Takikawa H

Clinical features of autoimmune hepatitis with acute presentation: a Japanese nationwide survey.

2018年 | J Gastroenterol 53 1079-1088 

学術論文

Isayama H, Tazuma S, Kokudo N, Tanaka A, Tsuyuguchi T, Nakazawa T, Notohara K, Mizuno S, Akamatsu N, Serikawa M, Naitoh I, Hirooka Y, Wakai T, Itoi T, Ebata T, Okaniwa S, Kamisawa T, Kawashima H, Kanno A, Kubota K, Tabata M, Unno M, Takikawa H

Clinical Guidelines for Primary Sclerosing Cholangitis 2017

2018年 | J Gastroenterol 53 1006-1034 

学術論文

Tanaka A, Hirohara J, Nakano T, Yagi M, Namisaki T, Yoshiji H, Hakanuma Y, Takikawa H

Effect of deferred or no treatment with ursodeoxycholic acid in patients with early primary biliary cholangitis.

2018年 | Hepatol Res 48 727-734 

学術論文

Takahashi A, Arinaga-Hino T, Ohira H, Abe K, Torimura T, Zeniya M, Abe M, Yoshizawa K, Takaki A, Suzuki Y, Kang J-H, Nakamoto N, Fujisawa T, Tanaka A, Takikawa H

Nonalcoholic fatty liver disease in patients with autoimmune hepatitis.

2018年 | JGH Open 2 54-58 

学術論文

Natsume M, Watanabe K, Matsumoto S, Naruge D, Hayashi K, Furuse J, Kawamura M, Jinno H, Sano K, Fukushima R, Osawa C, Aruga E, Hashiguchi Y, Tanaka A, Takikawa H, Seki N

Factors influencing cancer patients’ choice of end-of-life care place.

2018年 | J Palliat Med 21 751-765 

学術論文

Mawatari S, Moriuchi A, Ohba F, Kawano T, Oda K, Takikawa Y, Takikawa H, Ido A, Tsubouchi H

The recovery of the PT-INR to less than 1.3 predicts survival in patients with severe acute liver injury.

2018年 | J Gastroenterol 53 861-872 

学術論文

Sogo T, Takahashi A, Inui A, Fujisawa T, Ohira H, Takikawa H

Clinical features of pediatric autoimmune hepatitis in Japan: a nationwide survey

2018年 | Hepatol Res 48 186-294 

学術論文

Tanaka A, Tazuma S, Nakazawa T, Isayama H, Tsuyuguchi T, Inui K, Takikawa H

No negative impact of serum IgG4 levels on clinical outcome in 435 patients with primary sclerosing cholangitis from Japan.

2017年04月 | Journal of hepato-biliary-pancreatic sciences 24 4 217-225 

学術論文

Hiep NC, Harada K, Ouchi H, Sato Y, Tsuneyama K, Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang J-H, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya M, Ohira H, Tanaka A, Takikawa H

Acute presentation of autoimmune hepatitis: a multicenter study with detailed histologic evaluation in a large cohort of patients

2017年 | J Clin Pathol 70 961-969 

学術論文

Nakazawa T, Notohara K, Tazuma S, Tanaka A, Isayama H, Tsuyuguchi T, Mori T, Takikawa H

The 2016 diagnostic criteria for primary sclerosing cholangitis.

2017年 | J Gastroenterol 52 838-844 

学術論文

Tanaka A, Tazuma S, Okazaki K, Nakazawa T, Inui K, Chiba T, Takikawa H

Clinical features, treatment response, and outcome of IgG4-related sclerosing cholangitis.

2017年 | Clin Gastroenterol Hepatol 15 920-926 

学術論文

Takahashi A, Arinaga-Hino T, Ohira H, Torimura T, Zeniya M, Abe M, Yoshizawa K, Takaki A, Suzuki Y, Kang JH, Nakamoto N, Fujisawa T, Yonemoto K, Tanaka A, Takikawa H

Autoimmune hepatitis in Japan: trends in a nationwide survey.

2017年 | J Gastroenterol 52 631-640 

学術論文

Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senj

Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population

2017年 | Hum Mol Genet 26 650-659 

学術論文

Aiso M, Yagi M, Tanaka A, Miura K, Miura R, Arizumi T, Takamori Y, Nakahara S, Maruo Y, Takikawa H

Gilbert syndrome with concomitant hereditary spherocytosis presenting with moderate unconjugated hyperbilirubinemia

2017年 | Intern Med 56 661-664 

学術論文

Tanaka A, Ma X, Yokosuka O, Weltman M, You H, Amarapurkar DN, Kim YJ, Abbas Z, Payawal DA, Chang ML, Efe C, Ozaslan E, Abe M, Mitchell-Thain R, Zeniya M, Han KH, Vierling JM, Takikawa H

Autoimmune liver diseases in the Asia-Pacific region: Proceedings of APASL symposium on AIH and PBC 2016

2016年 | Hepatol Int 10 909-915 

学術論文

Mochida S, Nakao M, Nakayama N, Uchida Y, Nagoshi S, Ido A, Mimura T, Harigai M, Kaneko H, Kobayashi H, Tsuchida T, Suzuki H, Ura N, Nakamura Y, Bessho M, Dan K, Kusumoto S, Sasaki Y, Fujii H, Suzuki F, Ikeda K, Yamamoto K, Takikawa H, Tsubouchi H, M

Nationwide prospective and retrospective surveys for hepatitis B virus reactivation during immunosuppressive therapies.

2016年 | J Gastroenterol 51 999-1010 

学術論文

Tanaka A, Takikawa H, Mochida S, Koike K, Miwa H, Shimosegawa T

Changing nomenclature for PBC from "Primary Biliary Cirrhosis" to "Primary Biliary Cholangitis"

2016年 | J Gastroenterol 51 748-749 

学術論文

Mochida S, Nakayama N, Ido A, Takikawa Y, Yokosuka O, Sakaida I, Moriwaki H, Genda T, Takikawa H

Revised criteria for classification of the etiologies of acute liver failure and late-onset hepatic failure in Japan: A Report by the Intractable Hepato-Biliary Diseases Study Group of Japan in 2015.

2016年 | Hepatol Res 446 369-371 

学術論文

Tanaka A, Kikuchi K, Miura R, Miura K, Mikami M, Aiso M, Takamori Y, Takikawa H

Validation of the Japanese version of the Chronic Liver Disease Questionnaire (CLDQ) for the assessment of health-related quality of life in patients with chronic viral hepatitis

2016年 | Hepatol Res 46 E45-E50 

学術論文

Asahina Y, Izumi N, Hiromitsu K, Kurosaki M, Koike K, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H, Hayashi N, Hiramatsu N, Yotsuyanagi H

JSH Guidelines for the Management of Hepatitis C Virus Infection: A 2016 update for genotype 1 and 2

2016年 | Hepatol Res 46 129-165 

学術論文

Fujiwara K, Yokosuka O, Inoue K, Yasui S, Abe R, Oda S, Arata S, Takikawa Y, Ido A, Mochida S, Tsubouchi H, Takikawa H

Distribution of core hospitals for patients with fulminant hepatitis and late onset hepatic failure in Japan

2016年 | Hepatol Res 46 10-12 

学術論文

Nakamura M, Kondo H, Tanaka A, Komori A, Ito M, Yamamoto K, Ohira H, Zeniya M, Hashimoto E, Honda M, Kaneko S, Ueno Y, Kikuchi K, Shimoda S, Harada K, Arai K, Miyake Y, Abe M, Taniai M, Saibara T, Sakisaka S, Takikawa H, Onji M, Tsubouchi H, Nakanuma

Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis.

2015年08月 | Hepatology research : the official journal of the Japan Society of Hepatology 45 8 846-855 

学術論文

Tanaka A, Hirohara J, Nakanuma Y, Tsubouchi H, Takikawa H

Biochemical responses to bezafibrate improve long-term outcome in asymptomatic patients with primary biliary cirrhosis refractory to UDCA.

2015年06月 | Journal of gastroenterology 50 6 675-682 

学術論文

Tanaka A, Tazuma S, Okazaki K, Tsubouchi H, Inui K, Takikawa H

Clinical profiles of patients with primary sclerosing cholangitis in the elderly.

2015年03月 | Journal of hepato-biliary-pancreatic sciences 22 3 230-236 

学術論文

Adachi M, Tanaka A, Aiso M, Takamori Y, Takikawa H

The benefit of cystatin C in evaluation of renal function and prediction of survival in patients with cirrhosis

2015年 | Hepatol Res 45 1299-1306 

学術論文

Abe K, Miki A, Okamura T, Shimada K, Yamamoto T, Aiso M, Tanaka A, Kita H, Kuyama Y, Takikawa H

Endoscopic removal of a denture with clasps impacted in the ileocecum.

2014年12月 | Clinical journal of gastroenterology 7 6 506-509 

学術論文

Miyake Y, Yamamoto K, Matsushita H, Abe M, Takahashi A, Umemura T, Tanaka A, Nakamuta M, Nakamoto Y, Ueno Y, Saibara T, Takikawa H, Yoshizawa K, Ohira H, Zeniya M, Onji M, Tsubouchi H, Intractable Hepato-Biliary Disease Study Group of Japan.

Multicenter validation study of anti-programmed cell death-1 antibody as a serological marker for type 1 autoimmune hepatitis.

2014年12月 | Hepatology research : the official journal of the Japan Society of Hepatology 44 13 1299-1307 

学術論文

Hayashi H, Naoi S, Inoue T, Tanigawa Igarashi K, Nagasaka H, Kage M, Takikawa H, Sugiyama Y, Inui A, Kusuhara H.

IImproved liver function and relieved pruritus after 4-phenylbutyrate therapy in a patient with progressive familial intrahepatic cholestasis type 2.

2014年05月 | The Journal of pediatrics 164 5 1219-1227 

学術論文

Tanaka A, Tazuma S, Okazaki K, Tsubouchi H, Inui K, Takikawa H

Nationwide survey for primary sclerosing cholangitis and IgG4-related sclerosing cholangitis in Japan.

2014年01月 | Journal of hepato-biliary-pancreatic sciences 21 1 43-50 

学術論文

Asahina Y, Hayashi N, Niramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka Y, Tsubouchi H, Yotsuyanagi H.

JSH guidelines for the management of hepatitis B virus infection.

2014年 | Hepatol Res 44 suppl.1 1-58 

学術論文

Asahina Y, Hayashi N, Niramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka Y, Tsubouchi H, Yotsuyanagi H,

JSH guidelines for the management of hepatitis s C virus infection: A 2014 update for genotype 1.

2014年 | Hepatol Res 44 suppl.1 59-70 

学術論文

Komori A, Tanaka A, Takikawa H, Tsubouchi H, Ishibashi H, Wgawa H, Shirabe K, Harada K, Nakamuta M, Zenia M, Nakamura N, Fukushima N, Shimoda S, Sakisaka S, Morizane T, Takeyama Y, Nakanuma Y, Ueno Y.

Guidelines for the management of primary biliary cirrhosis.

2014年 | Hepatol Res 44 suppl.1 71-90 

学術論文

Tanaka A, Tazuma S, Okazaki K, Tsubouchi H, Inui K, Takikawa H

A national survey for primary sclerosing cholangitis and IgG4-related sclerosing cholangitis in Japan.

2014年 | J Hepatobiliary Pncreat Sci 21 43-50 

学術論文

Miura K, Tanaka A, Adachi M, Yamamoto T, Takikawa H.

Proton pump inhibitor use is associated with spontaneous bacterial peritonitis in patients with liver cirrhosis.

2014年 | Intern Med 53 10 1037-1042 

学術論文

Tanaka A, Takikawa H

Geoepidemiology of primary sclerosing cholangitis: a critical review.

2013年10月 | Journal of autoimmunity 46 35-40 

学術論文

Honda A, Ikegami T, Nakamuta M, Miyazaki T, Iwamoto J, Hirayama T, Saito Y, Takikawa H, Imawari M, Matsuzaki Y

Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid.

2013年05月 | 5 Hepatology (Baltimore, Md.) 57 5 1931-1941 

学術論文

Ishibashi H, Takikawa H, Nakao A, Watanabe M, Niwa Y, Nakamura T, Hokari R, Fukuzawa Y, Motoo Y, Morizane T, Sugano K

Revision of the training curriculum of Japan Society of Gastroenterology.

2013年05月 | 5 Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 110 5 788-795 

学術論文

Kumagai A, Fukushima J, Takikawa H, Fukuda T, Fukusato T

Enhanced expression of farnesoid X receptor in human hepatocellular carcinoma.

2013年01月 | Hepatology research : the official journal of the Japan Society of Hepatology 43 959-969 

学術論文

Asahina Y, Hayashi N, Niramatsu N, Izumi N, Koike K, Kumada H, Oketani M, Suzuki F, Takikawa H, Tanaka A, Tsubouchi H, Yotsuyanagi H.

Guidelines for the management of hepatitis C virus infection. First edition, May 2012, The Japan Society of Hepatology.

2013年 | Hepatol Res 43 1-34 

学術論文

Maekawa K, Futagami T, Kusunoki Y, Matsuzaki Y, Takikawa H.

Identification of a novel HLA-B allele HLA-B*07:185 in a Japanese individual.

2013年 | Tissure Antigens 8/2 434-436 

学術論文

Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.

2012年10月 | 4 American journal of human genetics 91 721-728 

学術論文

Ohara H, Okazaki K, Tsubouchi H, Inui K, Kawa S, Kamisawa T, Tazuma S, Uchida K, Hirano K, Yoshida H, Nishino T, Ko SB, Mizuno N, Hamano H, Kanno A, Notohara K, Hasebe O, Nakazawa T, Nakanuma Y, Takikawa H, Research Committee of IgG4-related Diseases

Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012.

2012年09月 | 5 Journal of hepato-biliary-pancreatic sciences 19 5 536-542 

学術論文

Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka

Involvement of SIK3 in glucose and lipid homeostasis in mice.

2012年 | 5 PloS one 7 e37803 

学術論文

Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H, Sugiyama Y

4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.

2012年 | J Hepatol 56 1136-1144 

学術論文

Mizuochi T, Kimura A, Tanaka A, Muto A, Nittono H, Seki Y, Takahashi T, Kurosawa T, Kage M, Takikawa H, Matsuishi T.

Characterization of urinary bile acids in a pediatric BRIC-1 patient: Effect of rifampicin treatment.

2012年 | Clin Chim Acta 413 1301-1304 

学術論文

Mitamura K, Hori N, Iida T, Suzuki M, Shimizu T, Nittono H, Takaori K, Takikawa H, Hofmann AF, Ikegawa S

Identification of S-acyl glutathione conjugates of bile acids in human bile by means of LC/ESI-MS.

2011年12月 | 14 Steroids 76 14 1609-1614 

学術論文

Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M, PERFECT Study Group

Cancer preventive effect of pegylated interferon α-2b plus ribavirin in a real-life clinical setting in Japan: PERFECT interim analysis.

2011年10月 | 10 Hepatology research : the official journal of the Japan Society of Hepatology 41 10 955-964 

学術論文

Fukami M, Tanka A, Takikawa H

Effect of penicillin G on the biliary excretion of cholephilic compounds in rats.

2011年09月 | 5 Journal of hepato-biliary-pancreatic sciences 18 5 684-688 

学術論文

Tanaka A, Harada K, Ebinuma H, Komori A, Yokokawa J, Yoshizawa K, Abe M, Miyake Y, Kikuchi K, Ohira H, Zeniya M, Yamamoto K, Ishibashi H, Onji M, Nakanuma Y, Tsubouchi H, Takikawa H

Primary biliary cirrhosis - Autoimmune hepatitis overlap syndrome: A rationale for corticosteroids use based on a nation-wide retrospective study in Japan.

2011年09月 | 9 Hepatology research : the official journal of the Japan Society of Hepatology 41 877-886 

学術論文

Miura R, Tanaka A, Takikawa H

Urinary bile acid sulfate levels in patients with primary biliary cirrhosis.

2011年04月 | 4 Hepatology research : the official journal of the Japan Society of Hepatology 41 4 358-363 

学術論文

Montali L, Tanaka A, Riva P, Takahashi H, Cocchi C, Ueno Y, Miglioretti M, Takikawa H, Vecchio L, Frigerio A, Bianchi I, Jorgensen R, Lindor KD, Podda M, Invernizzi P, Italian-Japanese PBC Study Group

A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis.

2010年10月 | 10 Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 42 718-723 

学術論文

Nagasaka H, Yorifuji T, Kobayashi K, Takikawa H, Komatsu H, Inui A, Fujisawa T, Miida T, Tsukahara H, Takatani T, Hayashi H

Favorable effect of 4-phenylacetate on liver functions attributable to enhanced bile salt export pump expression in ornithine transcarbamylase-deficient children.

2010年06月 | 2 Molecular genetics and metabolism 100 2 123-128 

学術論文

Goto H, Takikawa H

Effect of genipin on cholestasis induced by estradiol-17beta-glucuronide and lithocholate-3-O-glucuornide in rats.

2010年05月 | 5 Hepatology research : the official journal of the Japan Society of Hepatology 40 5 524-529 

学術論文

Watanabe S, Enomoto N, Koike K, Izumi N, Takikawa H, Hashimoto E, Moriyasu F, Kumada H, Imawari M, PERFECT Study Group

Prolonged treatment with pegylated interferon alpha 2b plus ribavirin improves sustained virological response in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan.

2010年02月 | 2 Hepatology research : the official journal of the Japan Society of Hepatology 40 2 135-144 

学術論文

Goto H, Tanaka A, Kondo F, Takeshita K, Nagashima I, Hanawa N, Aiso M, Takamori Y, Kato K, Takahashi Y, Fukushima J, Furui S, Fukusato T, Asano T, Takikawa H

Carcinosarcoma of the liver.

2010年 | 23 Internal medicine (Tokyo, Japan) 49 23 2577-2582 

その他

Recent status of drug-induced liver injury.

2009年 | Hepatol Res  

その他

Drug-induced liver injury in Japan – an analysis of 1,676 cases between 1997 and 2006.

2009年 | Hepatol Res  

その他

Molecular insights into β-galactoside α2,6-sialyltransferase secretion in vivo.

2009年 | Glycobiology  

その他

Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in both Japanese and Italian populations.

2009年 | J Hepatol  

その他

Resected case of eosinophilic cholangiopathy presenting with secondary sclerosing cholangitis.

2009年 | World J Gastroenterol  

その他

Effect of bile acids on the biliary excretion of pravastatin in rats.

2009年 | Hepatol Res  

その他

Urinary bile acid sulfate levels in patients with hepatitis C virus-related chronic liver diseases.

2009年 | Hepatol Res  

その他

Successful treatment with colestimide for a bout of cholestasis in a Japanese patient with benign recurrent intrahepatic cholestasis caused by ATP8B1 mutation.

2008年 | Intern Med  

その他

Effect of genipin on the biliary excretion of cholephilic compounds in rats.

2008年 | Hepatol Res  

その他

The outcome and prognostic factors of 391 Japanese patients with primary sclerosing cholangitis.

2008年 | Liver Int  

その他

Depletion of high-density lipoprotein and appearance of triglyceride-rich low-density lipoprotein in a Japanese patient with FIC1 deficiency manifesting benign recurrent intrahepatic cholestasis.

2007年 | J Pediatr Gastroenterol Nutr  

その他

Liver injury induced by levothyroxine in a patient with primary hyperthyroidism.

2007年 | Intern Med  

その他

The clinical significance of IgA antimitochondrial antibodies in sera and saliva in primary biliary cirrhosis.

2007年 | Ann NY Acad Sci  

その他

Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients of chronic hepatitis C.

2007年 | World J Gastroenterol  

その他

Characteristic of primary sclerosing cholangitis in Japan.

2007年 | Hepatol Res  

その他

Gene expression profiling in whole liver of bile duct ligated rats. VEGF-A expression is upregulated in hepatocytes adjacent to the portal tract -.

2007年 | J Gastroenterol Hepatol  

その他

Biliary excretion of sulfated bile acids and organic anions in zone 1- and zone 3-injured rats.

2006年 | J Gastroenterol Hepatol  

その他

Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats.

2006年 | Hepatol Res  

その他

Primary hepatic somatostatinoma in a patient with von Reckringhousen disease.

2006年 | J Gastroenterol  

その他

Drug-induced liver injury by dietary supplements in Japan.

2006年 | JMAJ  

その他

Tanaka A, Wada T, Maruyama M, Takikawa H, Komatsu Y

Hyperammonemia-induced encephalopathy due to ornithine transcarbomylase deficiency in an adult woman: identification of novel missence mutations.

2005年 | J Gastroenterol 40 106-107 

その他

Takayanagi M, Sano N, Takikawa H

Biliary excretion of olmesartan, an anigotensin II receptor antagonist, in the rat.

2005年 | J Gastroenterol Hepatol 20 784-788 

その他

Kurihara H, Sano N, Takikawa H

Biliary excretion of taurocholate, organic anions and vinblastine in rats with -naphthylisothiocyanate-induced cholestasis.

2005年 | J Gastroenterol Hepatol 20 1069-1074 

その他

Iwasa M, Zeniya M, Kumagi T, Hisamochi A, Yasuda H, Nishiuchi M, Akisawa N, Mantani N, Watanabe M, Ito T, Nakamura A, Takikawa H, Adachi Y

Modified diagnostic criteria of drug-induced liver injury proposed by the international consensus meeting.

2005年 | Hepatogastroenterology 52 869-874 

その他

Nagayama R, Tanaka N, Ankoh H, Narita T, Izumi M, Miyake K, Takikawa H

Efficacy of ribavirin monotherapy following combination therapy with interferon alfa 2b and ribavirin for patients with chronic hepatitis C.

2005年 | Hepatol Res 32 101-106 

その他

Takikawa H, Onji M

A proposal of the diagnostic scale of drug induced liver injury.

2005年 | Hepatol Res 32 250-251 

その他

Fukusato T, Fukushima J, Shiga J, Takahashi Y, Nakano T, Maeyama S, Uchikoshi M, Ohbu M, Matsumoto T, Matsumoto K, Hano H, Sakamoto M, Kondo F, Komatsu A, Ishikawa T, Ohtake H, Takikawa H, Yoshimura K

Interobserver variation in the histopathological assessment of nonalcoholic steatohepatitis

2005年 | Hepatol Res 33 122-127 

その他

Takikawa H

Lessons from ticlopidine-induced liver injury.

2005年 | Hepatol Res 33 193-194 

その他

Hanawa N, Sano N, Takikawa H

Biliary excretion of azelnidipine, a calcium antagonist, in rats

2004年 | Journal of Gastroenterology and Hepatology 19 413-417 

その他

TAKADA Y, TACHIZAWA H, KURIHARA H, TAKAYANAGI M, SASAMOTO T, AKASHI M, AISO M, TAKAMORI Y, SANO N

Comparison of urinary excretion of pravastatin and temocapril in bile duct ligated rats and Eisai hyperbilirubinemic rats (EHBR)

2004年 | Journal fo Hepato-Biliary-Pnacreatic Surgery 11 2 125-128 

その他

TAKIKAWA H, TAKAMORI Y, TANAKA A, KURIHARA H, NAKANUMA Y

Analysis of 388 cases of primary sclerosing cholangitis in Japan - Presence of a subgroup without pancreatic involvement in older patients -

2004年 | Hepatology Research 29 3 153-159 

その他

Tachizawa H, Sano N, Takikawa H

Effects of colchicine on the maximum biliary excretion of cholephilic compounds in rats

2004年 | Journal fo Gastroenterolgy and Hepatolgy 19 1016-1022 

その他

MARUMO T, FUKUSATO T, TAKIKAWA H

Biliary excretion of bile acids and organic anions in rats with dichloroethylene-induced bile canalicular injury

2004年 | Journal of Gastroenterology and Hepatology 39 10 981-987 

その他

Takeuchi A, Sano N, Takikawa H

Inhibition of ileal bile acid absorption by colestimide

2003年 | Journal of Gastroenterology and Hepatology 18 548-553 548-553 

その他

Hojo M, Sano N, Takikawa H

Effects of lipopolysaccharide on the biliary excretion of bile acids and organic anions in rats

2003年 | Journal of Gastroenterology and Hepatology 18 815-821 815-821 

その他

Mori M, Ishii T, Iida T, Tanaka F, Takikawa H, Okinaga K

Giant epithelial cyst of the accessory spleen

2003年 | Journal of Hepato-Biliary-Pancreatic Surgery 10 118-120 

その他

Takada Y, Sano N, Takikawa H

Urinary excretion of bile acids in bile duct-ligated rats

2003年 | Journal of Gastroenterology 38 561-566 

その他

Tanaka H, Sano N, Takikawa H

Biliary excretion of phenolphthalein sulfate in rats

2003年 | Pharmacology 68 177-182 

その他

滝川 一、高森頼雪、久持顕子、伊藤 正、熊木天児、渡辺真彰、中村篤志。新しい薬物性肝障害診断基準の提案—国際コンセンサス会議による診断基準の改定をもとにー

2003年 | 肝臓 44 . 176-179  

その他

薬物性肝障害の診断

2003年 | 日本消化器病学会雑誌 100 653-658 

その他

Suzuki C, Sano N, Takikawa H

Effect of dexamethasone on biliary excretion of bile acids and organic anions in rats

2003年 | Hepatology Research 25 48-54 48-54 

その他

TAKIKAWA H, TAKAMORI Y, KUMAGI T, ONJI M, WATANABE M, HISAMOCHI A, ITO T, MITSUMOTO Y, NAKAMURA A

Assessment of 287 Japanese cases of drug induced liver injury by the diagnostic scale of the International Consensus Meeting

2003年 | Hepatology Research 27 3 192-195 

その他

AKITA H, SUZUKI H, HIROHASHI T, TAKIKAWA H, SUGIYAMA Y

Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3

2002年 | Pharmaceutical Research 19 34-41 

その他

Onishi T, Sano N, Takikawa H

Effect of colestimide on absorpition of unconjugated bile acids in the rat jejunum

2002年 | Journal of Gastroenterology and Hepatolology 17 697-701 

その他

Ohashi M, Sano N, Takikawa H

Effect of phalloidin on biliary excretion of cholephilic compounds in rats

2002年 | Pharmacology 66 31-35 

その他

HASEGAWA Y, TAKIKAWA H

Effect of ursodeoxycholate-3, 7-disulgate on biliary excretion of lithocholate-3-O-glucronide in Eisai hyperbinemic rat(EHBR)

2002年 | Hepatology Research 23 4 296-300 

その他

TAKIKAWA H, SANO N, ONISHI T, TODA A, TANAKA H, HOJO M, MARUMO T, HANAWA N, NISHIKAWA K

Biliary excretion of taurolithocholate and temocaprilat in cholestatic rat induced by bile duct-ligation and ethinylestradiol

2002年 | Hepatology Research 24 2 136-140 

その他

TAKIKAWA H

Hepatobiliary transport of bile acids and organic anions.

2002年 | Journal of Hepto-Biliary-Pancreatic Surgery 9 4 443-447 

その他

TAKIKAWA H

Hepatobiliary transport of bile acids and organic anions

2002年 | Journal of Hepato-Biliary-Pnacreatic Surgery 9 4 443-447 

その他

TAKIKAWA H, SANO N, ONISHI T, OHASHI M, HASEGAWA Y, NISHIKAWA K

Biliary excretion of temocapril in zone 1-and zone 3-injured rat

2001年 | Hepatology Research 20 2 216-220 

その他

OGASAWARA T, TAKIKAWA H

Biliary excretion of phenolphthalein glucuronide in rat

2001年 | Hepatology Research 20 2 221-231 

その他

AKIMOTO K, SANO N, TAKIKAWA H

Biliary excretion of tauroursodeoxycholate-30sulfate in the rat

2001年 | Steroids 66 9 701-705 

その他

Takikawa H, Ogasawara T, Sato A, Ohashi M, Hasegawa Y, Hojo M.

Effect of colestimide on intestinal absorption of ursodeoxycholic acid in men

2001年 | International Journal of Clinical Pharmacology and Therapeutics 39 558-560 

その他

胆汁酸の肝細胞内輸送とその異常

1993年 | 胆と膵 14,717-722  

その他

C型慢性肝炎に対する経口剤治療

1993年 | カレントララピー 11,1772-1776  

その他

胆汁酸の肝内輸送と胆汁うつ滞

1993年 | 帝京医学雑誌 16,287-294