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経歴

【学歴】──────────────────────────────

1982年

東京大学医学部医

所属学会

日本血液学会

日本臨床血液学会

日本遺伝子治療学会

American society of Gene Therapy

日本造血細胞移植学会

日本内科学会

American Society of Hematology

European Society of Gene Therapy

International Sciety of Experimental Hematology

日本検査血液学会

専門分野

内科系臨床医学 血液内科学

研究テーマ

血液腫瘍学

職務上の実績

白血病に関する多型性の研究
siRNAを用いた血液腫瘍の治療実研

学術論文

Tashiro H, Shirasaki R, Watanabe M, Kawasugi K, Takahashi Y, Shirafuji N

Direct Factor X sequestration by systemic amyloid light-chain amyloidosis.

2018年03月 | Clinical case reports 6 3 513-515　

学術論文

Oka Y, Tashiro H, Sirasaki R, Yamamoto T, Akiyama N, Kawasugi K, Shirafuji N, Fujimori S

Hyperuricemia in hematologic malignancies is caused by an insufficient urinary excretion.

2014年 | Nucleosides, nucleotides & nucleic acids 33 4-6 434-438　

学術論文

Yoshimi M, Goyama S, Kawazu M, Nakagawa M, Ichikawa M, Imai Y, Kumano K, Asai T, Mulloy JC, Kraft AS, Takahashi T, Shirafuji N, Kurokawa M

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation.

2012年04月 | European journal of immunology 42 4 1044-1050　

学術論文

Shirasaki R, Tashiro H, Oka Y, Matsuo T, Yamamoto T, Sugao T, Akiyama N, Kawasugi K, Shirafuji N

Chronic Myelogenous Leukemia Cells Contribute to the Stromal Myofibroblasts in Leukemic NOD/SCID Mouse In Vivo.

2012年 | Journal of oncology 2012 901783　

学術論文

Sugimoto-Sekiguchi H, Tashiro H, Shirasaki R, Arai T, Yamamoto T, Oka Y, Akiyama N, Kawasugi K, Shirafuji N

Colonic EBV-Associated Lymphoproliferative Disorder in a Patient Treated with Rabbit Antithymocyte Globulin for Aplastic Anemia.

2012年 | Case reports in gastrointestinal medicine 2012 395801　

学術論文

Shirasaki R, Tashiro H, Oka Y, Sugao T, Yamamoto T, Yoshimi M, Akiyama N, Kawasugi K, Shirafuji N

Vascular endothelial growth factor-C and its receptor type-3 expressed in acute lymphocytic leukemia cases with t(1;19).

2011年08月 | International journal of hematology 94 2 203-208　

学術論文

Waki F, Masuoka K, Fukuda T, Kanda Y, Nakamae M, Yakushijin K, Togami K, Nishiwaki K, Ueda Y, Kawano F, Kasai M, Nagafuji K, Hagihara M, Hatanaka K, Taniwaki M, Maeda Y, Shirafuji N, Mori T, Utsunomiya A, Eto T, Nakagawa H, Murata M, Uchida T, Iida H

Feasibility of reduced-intensity cord blood transplantation as salvage therapy for graft failure: results of a nationwide survey of adult patients.

2011年06月 | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 17 6 841-851　

学術論文

Shirasaki R, Tashiro H, Mizutani-Noguchi M, Kawasugi K, Shirafuji N

Chronic myelogenous leukemia cells convert to myofibroblasts in vitro: effect of vascular endothelial growth factor on development of the microenvironment.

2011年05月 | Leukemia research 35 5 663-669　

学術論文

Tashiro H, Shirasaki R, Oka Y, Sugao T, Mizutani-Noguchi M, Yamamoto T, Akiyama N, Kawasugi K, Shirafuji N

FLT3 internal tandem duplication is associated with a high relapse rate and central nervous system involvement in acute promyelocytic leukemia cases: single institutional analysis.

2011年03月 | European journal of haematology 86 3 272-273　

学術論文

Tashiro H, Umezawa K, Shirota M, Oka Y, Shirasaki R, Nishi R, Taguchi A, Akiyama N, Kawasugi K, Ayabe T, Shirafuji N

[Acute myelogenous leukemia developed at the 26th week of gestation].

2011年01月 | [Rinsho ketsueki] The Japanese journal of clinical hematology 52 1 18-22　

学術論文

Oka Y, Tashiro H, Shirasaki R, Sugao T, Nishi R, Akiyama N, Kawasugi K, Fujimori S, Shirafuji N

Vascular endothelial growth factor acted as autocrine growth factor in an acute promyelocytic leukemia case.

2010年04月 | Leukemia & lymphoma 51 4 717-719　

学術論文

Yoshida H, Okumura N, Kitagishi Y, Shirafuji N, Matsuda S

Rab5(Q79L) interacts with the carboxyl terminus of RUFY3.

2010年04月 | International journal of biological sciences 6 2 187-189　

学術論文

Yamamoto T, Tashiro H, Sugao T, Oka Y, Shirasaki R, Kojima K, Akiyama N, Kawasugi K, Shirafuji N, Teramoto T

[Hypercalcemia due to the administration of all-trans retinoic acid for acute promyelocytic leukemia: report of two cases].

2010年04月 | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 99 4 828-830　

学術論文

Tashiro H, Mizutani-Noguchi M, Shirasaki R, Shirafuji N

Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.

2010年01月 | Biochemical and biophysical research communications 391 1 592-597　

学術論文

Oka Y, Tashiro H, Mizutani-Noguchi M, Koga I, Sugao T, Shirasaki R, Miura T, Akiyama N, Kawasugi K, Fujimori S, Shirafuji N

Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART.

2010年01月 | International journal of hematology 91 1 140-145　

学術論文

Matsuda S, Ichigotani Y, Okumura N, Yoshida H, Kajiya Y, Kitagishi Y, Shirafuji N

NESH protein expression switches to the adverse effect of imatinib mesylate.

2008年06月 | Molecular oncology 2 1 16-19　

学術論文

Noguchi M, Tashiro H, Shirasaki R, Gotoh M, Kawasugi K, Shirafuji N

Dual-specificity phosphatase 10 is fused to MDS1/EVI1-like gene 1 in a case of acute myelogenous leukemia with der1t1;1(p36.3;q21).

2007年02月 | International journal of hematology 85 2 175-176　

学術論文

Tashiro H, Shirasaki R, Noguchi M, Gotoh M, Kawasugi K, Shirafuji N

Molecular analysis of chronic eosinophilic leukemia with t(4;10) showing good response to imatinib mesylate.

2006年06月 | International journal of hematology 83 5 433-438　

学術論文

Takahashi S, Iseki T, Ooi J, Tomonari A, Takasugi K, Shimohakamada Y, Yamada T, Uchimaru K, Tojo A, Shirafuji N, Kodo H, Tani K, Takahashi T, Yamaguchi T, Asano S

Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies.

2004年12月 | Blood 104 12 3813-3820　

学術論文

Asano M, Nakae S, Kotani N, Shirafuji N, Nambu A, Hashimoto N, Kawashima H, Hirose M, Miyasaka M, Takasaki S, Iwakura Y

Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferase-I-deficient mice.

2003年09月 | Blood 102 5 1678-1685　

学術論文

Tomonari A, Shirafuji N, Tojo A, Iseki T, Ooi J, Komiya I, Tani K, Asano S

Acute myelogenous leukemia M5b developed during clinical remission of Castleman disease.

2003年04月 | International journal of hematology 77 3 274-276　

学術論文

Tomonari A, Tojo A, Iseki T, Ooi J, Hase H, Shirafuji N, Tani K, Asano S

Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy.

2003年 | Acta haematologica 109 2 90-94　

学術論文

Tomonari A, Iseki T, Ooi J, Takahashi S, Ishii K, Takahashi T, Shindo M, Nagamura F, Uchimaru K, Nagayama H, Shirafuji N, Tojo A, Tani K, Asano S

Using related donors other than genotypically HLA-matched siblings in allogeneic hematopoietic stem cell transplantation for hematologic disease: a single institution experience in Japan.

2002年11月 | International journal of hematology 76 4 354-359　

学術論文

Ooi J, Iseki T, Takahashi S, Tomonari A, Nagayama H, Ishii K, Ito K, Sato H, Takahashi T, Shindo M, Sekine R, Ohno N, Uchimaru K, Nagamura F, Shirafuji N, Tojo A, Tani K, Asano S

A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission.

2002年07月 | British journal of haematology 118 1 140-143　

学術論文

Oshima K, Machida K, Ichigotani Y, Nimura Y, Shirafuji N, Hamaguchi M, Matsuda S

SHPS-1: a budding molecule against cancer dissemination.

2002年07月 | Cancer research 62 14 3929-3933　

学術論文

Tomonari A, Shirafuji N, Iseki T, Ooi J, Nagayama H, Masunaga A, Tojo A, Tani K, Asano S

Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia.

2002年06月 | American journal of hematology 70 2 154-157　

学術論文

Tomonari A, Iseki T, Ooi J, Nagayama H, Sato H, Takahashi T, Ito K, Nagamura F, Uchimaru K, Takahashi S, Shirafuji N, Tojo A, Tani K, Asano S

Second allogeneic hematopoietic stem cell transplantation for leukemia relapse after first allogeneic transplantation: outcome of 16 patients in a single institution.

2002年04月 | International journal of hematology 75 3 318-323