電話番号

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研究室URL

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経歴

【学歴】──────────────────────────────

1982年

東京大学医学部

1982年

東京大学

所属学会

日本検査血液学会

International Sciety of Experimental Hematology

European Society of Gene Therapy

American Society of Hematology

日本内科学会

日本造血細胞移植学会

American society of Gene Therapy

日本遺伝子治療学会

日本臨床血液学会

日本血液学会

American Society of Gene Therapy

International Society for Cellular Therapy

専門分野

ライフサイエンス 血液、腫瘍内科学

研究テーマ

血液腫瘍学、Hemato-Oncology

職務上の実績

siRNAを用いた血液腫瘍の治療実研
白血病に関する多型性の研究

学術論文

Tashiro H, Shirasaki R, Watanabe M, Kawasugi K, Takahashi Y, Shirafuji N

Direct Factor X sequestration by systemic amyloid light-chain amyloidosis.

2018年03月 | Clinical case reports 6 3 513-515　

学術論文

Yoko Oka, Haruko Tashiro, Ryosuke Sirasaki, Tadashi Yamamoto, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji, Shin Fujimori

HYPERURICEMIA IN HEMATOLOGIC MALIGNANCIES IS CAUSED BY AN INSUFFICIENT URINARY EXCRETION

2014年 | TAYLOR & FRANCIS INC NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 33 4-6 434-438　

学術論文

Mayumi Yoshimi, Susumu Goyama, Masahito Kawazu, Masahiro Nakagawa, Motoshi Ichikawa, Yoichi Imai, Keiki Kumano, Takashi Asai, James C. Mulloy, Andrew S. Kraft, Tsuyoshi Takahashi, Naoki Shirafuji, Mineo Kurokawa

Multiple phosphorylation sites are important for RUNX1 activity in early hematopoiesis and T-cell differentiation

2012年04月 | WILEY-BLACKWELL EUROPEAN JOURNAL OF IMMUNOLOGY 42 4 1044-1050　

学術論文

Ryosuke Shirasaki, Haruko Tashiro, Yoko Oka, Takuji Matsuo, Tadashi Yamamoto, Toshihiko Sugao, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji

Chronic myelogenous leukemia cells contribute to the stromal myofibroblasts in Leukemic NOD/SCID mouse in vivo

2012年 | Journal of Oncology 2012 901783　

学術論文

Sugimoto-Sekiguchi H, Tashiro H, Shirasaki R, Arai T, Yamamoto T, Oka Y, Akiyama N, Kawasugi K, Shirafuji N

Colonic EBV-Associated Lymphoproliferative Disorder in a Patient Treated with Rabbit Antithymocyte Globulin for Aplastic Anemia.

2012年 | Case reports in gastrointestinal medicine 2012 395801　

学術論文

Ryosuke Shirasaki, Haruko Tashiro, Yoko Oka, Toshihiko Sugao, Tadashi Yamamoto, Mayumi Yoshimi, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji

Vascular endothelial growth factor-C and its receptor type-3 expressed in acute lymphocytic leukemia cases with t(1;19)

2011年08月 | SPRINGER TOKYO INTERNATIONAL JOURNAL OF HEMATOLOGY 94 2 203-208　

学術論文

Fusako Waki, Kazuhiro Masuoka, Takahiro Fukuda, Yoshinobu Kanda, Mika Nakamae, Kimikazu Yakushijin, Katsuhiro Togami, Kaichi Nishiwaki, Yasunori Ueda, Fumio Kawano, Masaharu Kasai, Koji Nagafuji, Maki Hagihara, Kazuo Hatanaka, Masafumi Taniwaki, Yosh

Feasibility of Reduced-Intensity Cord Blood Transplantation as Salvage Therapy for Graft Failure: Results of a Nationwide Survey of Adult Patients

2011年06月 | ELSEVIER SCIENCE INC BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 17 6 841-851　

学術論文

Ryosuke Shirasaki, Haruko Tashiro, Mitsuho Mizutani-Noguchi, Kazuo Kawasugi, Naoki Shirafuji

Chronic myelogenous leukemia cells convert to myofibroblasts in vitro: Effect of vascular endothelial growth factor on development of the microenvironment

2011年05月 | PERGAMON-ELSEVIER SCIENCE LTD LEUKEMIA RESEARCH 35 5 663-669　

学術論文

Haruko Tashiro, Ryosuke Shirasaki, Yoko Oka, Toshihiko Sugao, Mitsuho Mizutani-Noguchi, Tadashi Yamamoto, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji

FLT3 internal tandem duplication is associated with a high relapse rate and central nervous system involvement in acute promyelocytic leukemia cases: single institutional analysis

2011年03月 | WILEY-BLACKWELL EUROPEAN JOURNAL OF HAEMATOLOGY 86 3 272-273　

学術論文

Tashiro H, Umezawa K, Shirota M, Oka Y, Shirasaki R, Nishi R, Taguchi A, Akiyama N, Kawasugi K, Ayabe T, Shirafuji N

[Acute myelogenous leukemia developed at the 26th week of gestation].

2011年01月 | [Rinsho ketsueki] The Japanese journal of clinical hematology 52 1 18-22　

学術論文

Yoko Oka, Haruko Tashiro, Ryosuke Shirasaki, Toshihiko Sugao, Ryuichi Nishi, Nobu Akiyama, Kazuo Kawasugi, Shin Fujimori, Naoki Shirafuji

Vascular endothelial growth factor acted as autocrine growth factor in an acute promyelocytic leukemia case

2010年04月 | TAYLOR & FRANCIS LTD LEUKEMIA & LYMPHOMA 51 4 717-719　

学術論文

Yamamoto T, Tashiro H, Sugao T, Oka Y, Shirasaki R, Kojima K, Akiyama N, Kawasugi K, Shirafuji N, Teramoto T

[Hypercalcemia due to the administration of all-trans retinoic acid for acute promyelocytic leukemia: report of two cases].

2010年04月 | Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 99 4 828-830　

学術論文

Haruko Tashiro, Mitsuho Mizutani-Noguchi, Ryosuke Shirasaki, Naoki Shirafuji

Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts

2010年01月 | ACADEMIC PRESS INC ELSEVIER SCIENCE BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 391 1 592-597　

学術論文

Yoko Oka, Haruko Tashiro, Mitsuho Mizutani-Noguchi, Ichiro Koga, Toshihiko Sugao, Ryosuke Shirasaki, Toshiyuki Miura, Nobu Akiyama, Kazuo Kawasugi, Shin Fujimori, Naoki Shirafuji

Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART

2010年01月 | SPRINGER TOKYO INTERNATIONAL JOURNAL OF HEMATOLOGY 91 1 140-145　

学術論文

Hitomi Yoshida, Naoko Okumura, Yasuko Kitagishi, Naoki Shirafuji, Satoru Matsuda

Rab5(Q79L) interacts with the carboxyl terminus of RUFY3

2010年 | IVYSPRING INT PUBL INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 6 2 187-189　

学術論文

Satoru Matsuda, Yasukatu Ichigotani, Naoko Okumura, Hitomi Yoshida, Yuka Kajiya, Yasuko Kitagishi, Naoki Shirafuji

NESH protein expression switches to the adverse effect of imatinib mesylate

2008年06月 | ELSEVIER SCI LTD MOLECULAR ONCOLOGY 2 1 16-19　

学術論文

Mitsuho Noguchi, Haruko Tashiro, Ryosuke Shirasaki, Moritaka Gotoh, Kazuo Kawasugi, Naoki Shirafuji

Dual-specificity phosphatase 10 is fused to MDS1/EVI1-like gene 1 in a case of acute myelogenous leukemia with der(1)t(1;1)(p36.3;q21)

2007年02月 | CARDEN JENNINGS PUBL CO LTD INTERNATIONAL JOURNAL OF HEMATOLOGY 85 2 175-176　

学術論文

H Tashiro, R Shirasaki, M Noguchi, M Gotoh, K Kawasugi, N Shirafuji

Molecular analysis of chronic eosinophilic leukemia with t(4;10) showing good response to imatinib mesylate

2006年06月 | CARDEN JENNINGS PUBL CO LTD INTERNATIONAL JOURNAL OF HEMATOLOGY 83 5 433-438　

学術論文

S Takahashi, T Iseki, J Ooi, A Tomonari, K Takasugi, Y Shimohakamada, T Yamada, K Uchimaru, A Tojo, N Shirafuji, H Kodo, K Tani, T Takahashi, T Yamaguchi, S Asano

Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies

2004年12月 | AMER SOC HEMATOLOGY BLOOD 104 12 3813-3820　

学術論文

M Asano, S Nakae, N Kotani, N Shirafuji, A Nambu, N Hashimoto, H Kawashima, M Hirose, M Miyasaka, S Takasaki, Y Iwakura

Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferdse-I-deficient mice

2003年09月 | AMER SOC HEMATOLOGY BLOOD 102 5 1678-1685　

学術論文

A Tomonari, N Shirafuji, A Tojo, T Iseki, J Ooi, Komiya, I, K Tani, S Asano

Acute myelogenous leukemia M5b developed during clinical remission of Castleman disease

2003年04月 | CARDEN JENNINGS PUBL CO LTD INTERNATIONAL JOURNAL OF HEMATOLOGY 77 3 274-276　

学術論文

A Tomonari, A Tojo, T Iseki, J Ooi, H Hase, N Shirafuji, K Tani, S Asano

Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy

2003年 | KARGER ACTA HAEMATOLOGICA 109 2 90-94　

学術論文

A Tomonari, T Iseki, J Ooi, S Takahashi, K Ishii, T Takahashi, M Shindo, F Nagamura, K Uchimaru, H Nagayama, N Shirafuji, A Tojo, K Tani, S Asano

Using related donors other than genotypically HLA-matched siblings in allogeneic hematopoietic stem cell transplantation for hematologic disease: A single institution experience in Japan

2002年11月 | CARDEN JENNINGS PUBL CO LTD INTERNATIONAL JOURNAL OF HEMATOLOGY 76 4 354-359　

学術論文

J Ooi, T Iseki, S Takahashi, A Tomonari, H Nagayama, K Ishii, K Ito, H Sato, T Takahashi, M Shindo, R Sekine, N Ohno, K Uchimaru, F Nagamura, N Shirafuji, A Tojo, K Tani, S Asano

A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission

2002年07月 | BLACKWELL PUBLISHING LTD BRITISH JOURNAL OF HAEMATOLOGY 118 1 140-143　

学術論文

K Oshima, K Machida, Y Ichigotani, Y Nimura, N Shirafuji, M Hamaguchi, S Matsuda

SHPS-1: A budding molecule against cancer dissemination

2002年07月 | AMER ASSOC CANCER RESEARCH CANCER RESEARCH 62 14 3929-3933　

学術論文

A Tomonari, N Shirafuji, T Iseki, J Ooi, H Nagayama, A Masunaga, A Tojo, K Tani, S Asano

Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia

2002年06月 | WILEY-LISS AMERICAN JOURNAL OF HEMATOLOGY 70 2 154-157　

学術論文

A Tomonari, T Iseki, J Ooi, H Nagayama, H Sato, T Takahashi, K Ito, F Nagamura, K Uchimaru, S Takahashi, N Shirafuji, A Tojo, K Tani, S Asano

Second allogeneic hematopoietic stem cell transplantation for leukemia relapse after first allogeneic transplantation: Outcome of 16 patients in a single institution

2002年04月 | CARDEN JENNINGS PUBL CO LTD INTERNATIONAL JOURNAL OF HEMATOLOGY 75 3 318-323　

その他

N Shirafuji, S Takahashi, S Matsuda, S Asano

Mitochondrial antisense RNA for cytochrome C oxidase (MARCO) can induce morphologic changes and cell death in human hematopoietic cell lines

1997年12月 | W B SAUNDERS CO BLOOD 90 11 4567-4577　

その他

T TANAKA, S AKIRA, K YOSHIDA, M UMEMOTO, Y YONEDA, N SHIRAFUJI, H FUJIWARA, S SUEMATSU, N YOSHIDA, T KISHIMOTO

TARGETED DISRUPTION OF THE NF-IL6 GENE DISCLOSES ITS ESSENTIAL ROLE IN BACTERIA KILLING AND TUMOR-CYTOTOXICITY BY MACROPHAGES

1995年01月 | CELL PRESS CELL 80 2 353-361　

その他

Recombinant human glycosylated granulocyte colony-stimulating factor CrhG-(SF)-combined reginen for allugeneic bonemarrow tyansplantation in refractony acute myeloid leukemia

1994年 | Bone Marrow Transplantation 13 239　

その他

Expression of granuloalte and granuloute-macrophage colony-stimulating factors by human nru-hematopoietic tumor colls.

1990年 | Growth Factors 3 325　

その他

Granulocyte colony-stimulating factor stimulates human mature neutrophilic granulocytes to produce interferon-α

1990年 | BLOOD 75 1 17　

その他

N SHIRAFUJI, S ASANO, S MATSUDA, K WATARI, F TAKAKU, S NAGATA

A NEW BIOASSAY FOR HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (HG-CSF) USING MURINE MYELOBLASTIC NFS-60 CELLS AS TARGETS AND ESTIMATION OF ITS LEVELS IN SERA FROM NORMAL HEALTHY-PERSONS AND PATIENTS WITH INFECTIOUS AND HEMATOLOGICAL DISORDERS

1989年02月 | CARDEN JENNINGS PUBL CO LTD EXPERIMENTAL HEMATOLOGY 17 2 116-119　

その他

Serum granulocyte colony-stimulating factor levels in healthy volunteers and patieuts with various disorders as estimated by enzyme immunoassay

1989年 | BLOOD 73 117　

その他

Human granulocyte colony-stimulating factor Specifically binds to murine myeloblasfic NFS-60 cells and activates their huanosine triphosphate binding proteins/adenylate cyclase system.

1989年 | BLOOD 74 2343　

その他

Production of granulocyte colony-stimulating factry byacute myelomonocytic leukemia cells

1988年 | Leukemia Research 12 745　

その他

M TAMURA, K HATTORI, H NOMURA, M OHEDA, N KUBOTA, IMAZEKI, I, M ONO, Y UEYAMA, S NAGATA, N SHIRAFUJI, S ASANO

INDUCTION OF NEUTROPHILIC GRANULOCYTOSIS IN MICE BY ADMINISTRATION OF PURIFIED HUMAN NATIVE GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF)

1987年01月 | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 142 2 454-460