帝京大学

新見 正則 准教授

Niimi Masanori

所属キャンパス板橋キャンパス

帝京大学 医学部 医学科 板橋キャンパス 臨床医学講座・診療科 外科学講座

 

連絡先

研究室URL

http://www.mniimi.com

経歴・所属学会・専門分野・研究テーマ

経歴

【学歴】──────────────────────────────

1998年

オックスフォード大学外科移植免疫学

1985年

慶應義塾大学医学部医学科

【受賞】──────────────────────────────

1998年

American Society of Transplant physician Young lnvestigator award

所属学会

日本外科学会

日本消化器外科学会

日本移植学会

ASTP

日本免疫学会

専門分野

基礎医学 免疫学、外科系臨床医学 外科学一般

研究テーマ

血管外科、移植免疫学、腫瘍免疫学、東洋医学

教育方法・職務上の実績

情報がありません

著書・論文

学術論文

Jin X, Uchiyama M, Zhang Q, Niimi M

Fox smell abrogates the effect of herbal odor to prolong mouse cardiac allograft survival.

2014年05月 | 1 Journal of cardiothoracic surgery 9 82 

学術論文

Uchiyama M, Jin X, Matsuda H, Bashuda H, Imazuru T, Shimokawa T, Yagita H, Niimi M

An agonistic anti-BTLA mAb (3C10) induced generation of IL-10-dependent regulatory CD4+ T cells and prolongation of murine cardiac allograft.

2014年02月 | 3 Transplantation 97 301-309 

学術論文

Takasato F, Morita R, Schichita T, Sekiya T, Morikawa Y, Kuroda T, Niimi M, Yoshimura A

Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells.

2014年 | 2 PloS one 9 e87722 

学術論文

Jin X, Yu L, Uchiyama M, Yin E, Harada T, Otsuka K, Matsuyama S, Imazuru T, Shimokawa T, Niimi M

Combination of paeoniae radix and cnidii rhizoma prolonged survival of fully mismatched cardiac allografts and generated regulatory cells in mice.

2014年 | Evidence-based complementary and alternative medicine : eCAM 2014 841408 

学術論文

Kaburaki T, Zhang Q, Jin X, Uchiyama M, Fujino Y, Nakahara H, Takamoto M, Otomo K, Niimi M

Effects of Japanese herbal medicine Sairei-to on murine experimental autoimmune uveitis.

2013年12月 | 12 Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 251 2733-2739 

学術論文

Uchiyama M, Jin X, Zhang Q, Hirai T, Bashuda H, Watanabe T, Amano A, Niimi M

Danazol induces prolonged survival of fully allogeneic cardiac grafts and maintains the generation of regulatory CD4(+) cells in mice.

2012年03月 | 3 Transplant international : official journal of the European Society for Organ Transplantation 25 357-365 

学術論文

Uchiyama M, Jin X, Zhang Q, Hirai T, Amano A, Bashuda H, Niimi M

Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4+CD25+ cells.

2012年03月 | Journal of cardiothoracic surgery 7 26 

学術論文

Jin X, Uchiyama M, Zhang Q, Hirai T, Niimi M

Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice.

2012年 | Evidence-based complementary and alternative medicine : eCAM 2012 689810 

学術論文

Zhang Q, Uchiyama M, Jin X, Iwami D, Shirasugi N, Watanabe T, Niimi M

Induction of regulatory T cells and prolongation of survival of fully allogeneic cardiac grafts by administration of Tokishakuyaku-san in mice.

2011年11月 | 5 Surgery 150 923-933 

学術論文

Iwami D, Nonomura K, Shirasugi N, Niimi M

Immunomodulatory effects of eicosapentaenoic acid through induction of regulatory T cells.

2011年03月 | 3 International immunopharmacology 11 384-389 

学術論文

Iwami D, Zhang Q, Aramaki O, Matsuno K, Nonomura K, Shirasugi N, Niimi M

Depletion of alveolar macrophages abrogates prolongation of cardiac allograft survival induced by intratracheal delivery of alloantigen.

2011年02月 | 4 Transplantation 91 413-424 

学術論文

Zhang Q, Jin X, Uchiyama M, Yakubo S, Niimi M

Impact of sairei-to and its individual constituents on cardiac allograft survival.

2010年07月 | 7 The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 29 818-820 

学術論文

Zhang Q, Nakaki T, Iwami D, Niimi M, Shirasugi N

Induction of regulatory T cells and indefinite survival of fully allogeneic cardiac grafts by ursodeoxycholic acid in mice.

2009年12月 | 12 Transplantation 88 1360-1370 

学術論文

Zhang Q, Iwami D, Aramaki O, Yakubo S, Nishimura K, Ishige A, Watanabe K, Matsuno K, Shirasugi N, Niimi M

Prolonged survival of fully mismatched cardiac allografts and generation of regulatory cells by Sairei-to, a Japanese herbal medicine.

2009年06月 | 12 Transplantation 87 1787-1791 

学術論文

Takeuchi T, Nakao M, Kohno M, Hatano M, Niimi M, Yano E

Development of a questionnaire to assess 'Hie' symptoms using an evidence-based analysis.

2008年11月 | 6 Environmental health and preventive medicine 13 338-344 

学術論文

Inoue F, Zhang Q, Akiyoshi T, Aramaki O, Iwami D, Matsumoto K, Kitagawa Y, Shirasugi N, Niimi M

Prolongation of survival of fully allogeneic cardiac grafts and generation of regulatory cells by a histamine receptor 2 antagonist.

2007年11月 | 10 Transplantation 84 1288-1297 

学術論文

Akiyoshi T, Zhang Q, Inoue F, Aramaki O, Hatano M, Shimazu M, Kitajima M, Shirasugi N, Niimi M

Induction of indefinite survival of fully mismatched cardiac allografts and generation of regulatory cells by sarpogrelate hydrochloride.

2006年10月 | 8 Transplantation 82 1051-1059 

学術論文

Ikeda Y, Morita N, Kurihara H, Niimi M, Okinaga K

A primary aortoesophageal fistula due to esophageal carcinoma successfully treated with endoluminal aortic stent grafting.

2006年02月 | 2 The Journal of thoracic and cardiovascular surgery 131 486-487 

学術論文

Yokoyama T, Aramaki O, Takayama T, Takano S, Zhang Q, Shimazu M, Kitajima M, Ikeda Y, Shirasugi N, Niimi M

Selective cyclooxygenase 2 inhibitor induces indefinite survival of fully allogeneic cardiac grafts and generates CD4+ regulatory cells.

2005年10月 | 4 The Journal of thoracic and cardiovascular surgery 130 1167-1174 

学術論文

Shibutani S, Inoue F, Aramaki O, Akiyama Y, Matsumoto K, Shimazu M, Kitajima M, Ikeda Y, Shirasugi N, Niimi M

Effects of immunosuppressants on induction of regulatory cells after intratracheal delivery of alloantigen.

2005年04月 | 8 Transplantation 79 904-913 

学術論文

Aramaki O, Inoue F, Takayama T, Shimazu M, Kitajima M, Ikeda Y, Okumura K, Yagita H, Shirasugi N, Niimi M

Interleukin-10 but not transforming growth factor-beta is essential for generation and suppressor function of regulatory cells induced by intratracheal delivery of alloantigen.

2005年03月 | 5 Transplantation 79 568-576 

学術論文

Ikeda Y, Kurihara H, Niimi M, Kodaira S

Esophageal intramural spreading from an adenocarcinoma of the esophagogastric junction.

2004年09月 | 59 Hepato-gastroenterology 51 1382-1383 

学術論文

Aramaki O, Shirasugi N, Takayama T, Shimazu M, Kitajima M, Ikeda Y, Azuma M, Okumura K, Yagita H, Niimi M

Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen.

2004年01月 | 1 Transplantation 77 6-12 

学術論文

Aramaki O, Shirasugi N, Akiyama Y, Takayama T, Shimazu M, Kitajima M, Ikeda Y, Niimi M

Induction of operational tolerance and generation of regulatory cells after intratracheal delivery of alloantigen combined with nondepleting anti-CD4 monoclonal antibody.

2003年11月 | 9 Transplantation 76 1305-1314 

学術論文

Aramaki O, Shirasugi N, Akiyama Y, Shibutani S, Takayama T, Shimazu M, Kitajima M, Ikeda Y, Okumura K, Yagita H, Niimi M

CD27/CD70, CD134/CD134 ligand, and CD30/CD153 pathways are independently essential for generation of regulatory cells after intratracheal delivery of alloantigen.

2003年09月 | 5 Transplantation 76 772-776 

学術論文

Aramaki O, Shirasugi N, Akiyama Y, Ikeda Y, Yabuki S, Shimazu M, Kitajima M, Niimi M

Prolonged survival of fully allogeneic cardiac grafts in naive mice and those with sensitization induced by antigen delivery through the respiratory tract.

2003年09月 | 3 The Journal of thoracic and cardiovascular surgery 126 853-854 

学術論文

Ikeda Y, Tobari S, Niimi M, Kan S, Takami H, Kodaira S

Reliable cervical anastomosis through the retrosternal route with stepwise gastric tube.

2003年06月 | 6 The Journal of thoracic and cardiovascular surgery 125 1306-1312 

学術論文

Ikeda Y, Tobari S, Niimi M, Kodaira S, Okinaga K

Second primary double carcinomas of the residual cervical esophagus and the gastric tube after thoracic esophagectomy.

2003年06月 | 6 The Journal of thoracic and cardiovascular surgery 125 1561-1562 

学術論文

Shirasugi N, Akiyama Y, Aramaki O, Shibutani S, Matsumoto K, Bashuda H, Yagita H, Okumura K, Ikeda Y, Niimi M

Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen.

2003年05月 | 10 Transplantation 75 1636-1639 

学術論文

Uchida N, Shirasugi N, Akiyama Y, Matsumoto K, Shimazu M, Kitajima M, Hamano K, Aramaki O, Ikeda Y, Niimi M

Induction of indefinite survival of fully allogeneic cardiac grafts and generation of regulatory cells by intratracheal delivery of alloantigens under blockade of the CD40 pathway.

2003年03月 | 6 Transplantation 75 878-884 

学術論文

Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S

Conformal radiation therapy for liver metastasis of esophageal carcinoma.

2003年03月 | 50 Hepato-gastroenterology 50 532-534 

学術論文

Ikeda Y, Takami H, Sasaki Y, Takayama J, Niimi M, Kan S

Clinical benefits in endoscopic thyroidectomy by the axillary approach.

2003年02月 | 2 Journal of the American College of Surgeons 196 189-195 

学術論文

Aramaki O, Takayama T, Yokoyama T, Takano S, Akiyama Y, Shibutani S, Matsumoto K, Shimazu M, Kitajima M, Ikeda Y, Shirasugi N, Niimi M

High dose of antithrombin III induces indefinite survival of fully allogeneic cardiac grafts and generates regulatory cells.

2003年01月 | 2 Transplantation 75 217-220 

学術論文

Akiyama Y, Shirasugi N, Aramaki O, Matsumoto K, Shimazu M, Kitajima M, Ikeda Y, Niimi M

Intratracheal delivery of a single major histocompatibility complex class I peptide induced prolonged survival of fully allogeneic cardiac grafts and generated regulatory cells.

2002年10月 | 10 Human immunology 63 888-892 

学術論文

Ikeda Y, Sasaki Y, Niimi M, Kan S, Takami H, Kodaira S

Hand-assisted laparoscopic proximal gastrectomy with jejunal interposition and lymphadenectomy.

2002年10月 | 4 Journal of the American College of Surgeons 195 578-581 

学術論文

Akiyama Y, Shirasugi N, Uchida N, Matsumoto K, Kitajima M, Bashuda H, Yagita H, Okumura K, Aramaki O, Niimi M

B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice.

2002年09月 | 5 Transplantation 74 732-738 

学術論文

Ikeda Y, Takami H, Sasaki Y, Takayama J, Kan S, Niimi M

Minimally invasive video-assisted thyroidectomy and lymphadenectomy for micropapillary carcinoma of the thyroid.

2002年08月 | 4 Journal of surgical oncology 80 218-221 

学術論文

Niimi M, Ikeda Y, Kan S, Takami H

Gas gangrene in patient with atherosclerosis obliterans.

2002年06月 | 2 Asian cardiovascular & thoracic annals 10 178-180 

学術論文

Ikeda Y, Niimi M, Kan S, Takami H, Kodaira S

Thoracoscopic esophagectomy combined with mediastinoscopy via the neck.

2002年04月 | 4 The Annals of thoracic surgery 73 1329-1331 

学術論文

Niimi M, Ikeda Y, Kan S, Takami H, Furui S, Takeshita K

Re: spontaneous rupture of an intercostal artery due to neurofibromatosis type I disease treated by percutaneous embolization.

2002年03月 | 2 Cardiovascular and interventional radiology 25 160-161 

学術論文

Shatari T, Fujita M, Nozawa K, Haku K, Niimi M, Ikeda Y, Kan S, Kodaira S

Feasibility of dividing the main vessels for enhancement of dynamic graciloplasty.

2002年 | 11 Surgery today 32 974-980 

学術論文

Ikeda Y, Takami H, Tajima G, Sasaki Y, Takayama J, Kurihara H, Niimi M

Direct mini-incision parathyroidectomy.

2002年 | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 56 Suppl 1 14s-17s 

学術論文

Ikeda Y, Takami H, Tajima G, Sasaki Y, Takayama J, Kurihara H, Niimi M

Direct mini-incision thyroidectomy.

2002年 | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 56 Suppl 1 60s-63s 

その他

Ikeda Y, Takami H, Sasaki Y, Takayama J, Kan S, Niimi M. Minimally invasive video-assisted thyroidectomy and lymphadenectomy for micropapillary carcinoma of the thyroid.

2002年 | J Surg Oncol 80(4), 218-21  

その他

Ikeda Y, Takami H, Sasaki Y, Takayama J, Niimi M, Kan S. Comparative study of thyroidectomies.

2002年 | Surg Endosc 29, 29  

その他

Ikeda Y, Sasaki Y, Niimi M, Kan S, Takami H, Kodaira S. Hand-assisted laparoscopic proximal gastrectomy with jejunal interposition and lymphadenectomy.

2002年 | J Am Coll Surg 195(4), 578-81  

その他

Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y, Takayama J. Endoscopic total parathyroidectomy by the anterior chest approach for renal hyperparathyroidism.

2002年 | Surg Endosc 16(2), 320-2  

その他

Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y, Takayama J. Endoscopic thyroidectomy and parathyroidectomy by the axillary approach. A preliminary report.

2002年 | Surg Endosc 16(1), 92-5  

その他

Ikeda Y, Niimi M, Kan S, Takami H, Kodaira S. Thoracoscopic esophagectomy combined with mediastinoscopy via the neck.

2002年 | Ann Thorac Surg 73(4), 1329-31  

その他

Yokoyama T, Aramaki O, Takano S, Takayama T, Akiyama Y, Shibutani S, Shirasugi N, Kan S, Ikeda Y, Niimi M. Cyclooxygenase-2 inhibitor induces operational tolerance to fully allogenic cardiac grafts.

2002年 | Transplant Proc 34(5), 1405  

その他

Shibutani S, Akiyama Y, Shirasugi N, Matsumoto K, Kitajima M, Aramaki O, Yokoyama T, Kan S, Ikeda Y, Niimi M. FK 506 abrogates induction of regulatory cells after intratracheal delivery of alloantigen.

2002年 | Transplant Proc 34(5), 1445  

その他

Niimi M, Ikeda Y, Kan S, Takami H. Gas gangrene in patient with atherosclerosis obliterans.

2002年 | Asian Cardiovasc Thorac Ann 10(2), 178-80  

その他

Niimi M, Ikeda Y, Kan S, Takami H. Superficialization of hemodialysis access using a video-assisted procedure.

2002年 | Surg Endosc 16(1), 218  

その他

Niimi M, Ikeda Y, Kan S, Takami H, Furui S, Takeshita K. Re: spontaneous rupture of an intercostal artery due to neurofibromatosis type Ⅰ disease treated by percutaneous embolization.

2002年 | Cardiovasc Intervent Radiol 25(2), 160-1  

その他

Akiyama Y, Shirasugi N, Uchida N, Matsumoto K, Kitajima M, Bashuda H, Yagita H, Okumura K, Aramaki O, Niimi M. B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice.

2002年 | Transplantation 74(5), 732-8  

その他

Akiyama Y, Shirasugi N, Aramaki O, Matsumoto K, Shimazu M, Kitajima M, Ikeda Y, Niimi M. Intratracheal delivery of a single major histocompatibility complex class Ⅰ peptide induced prolonged survival of fully allogeneic cardiac grafts and generated r

2002年 | Hum Immunol 63(10), 888  

その他

Aramaki O, Takayama T, Yokoyama T, Takano S, Akiyama Y, Shibutani S, Shirasugi N, Kan S, Ikeda Y, Niimi M. Intravenous administration of antithrombin Ⅲ induces indefinite survival of fully allogeneic cardiac grafts.

2002年 | Transplant Proc 34(5), 1409  

その他

Akiyama Y, Shibutani S, Matsumoto K, Kitajima M, Aramaki O, Yokoyama T, Kan S, Ikeda Y, Shirasugi N, Niimi M. Induction of prolonged survival of fully allogeneic cardiac graft by intratracheal delivery of a single major histocompatability complex cla

2002年 | Transplant Proc 34(5), 1396  

その他

Akiyama Y, Shibutani S, Matsumoto K, Kitajima M, Aramaki O, Yokoyama T, Kan S, Ikeda Y, Shirasugi N, Niimi M. CD25(+) regulatory cells generated by intratracheal delivery of alloantigen.

2002年 | Transplant Proc 34(5), 1443  

その他

Niimi M, Shirasugi N, Ikeda Y, Wood KJ. Oral antigen induces allograft survival by linked suppression via the indirect pathway.

2001年 | Transplant Proc 33(1-2), 81  

その他

Niimi M. The technique for heterotopic cardiac transplantation in mice: experience of 3000 operations by one surgeon.

2001年 | J Heart Lung Transplant 20(10), 1123-8  

その他

Niimi M, Ikeda Y, Kan S, Shirasugi N, Hamano K. Indefinite survival of fully allogeneic cardiac grafts induced by antigen delivery through the alimentary tract.

2001年 | J Thorac Cardiovasc Surg 122(3), 629-30  

その他

Niimi M, Shirasugi N, Ikeda Y, Kan S, Takami H, Hamano K. Importance of thymus to maintain operational tolerance to fully allogeneic cardiac grafts.

2001年 | Ann Thorac Surg 72(3), 735-9  

その他

Niimi M, Shirasugi N, Ikeda Y, Kan S, Takami H, Hamano K. Operational tolerance induced by pretreatment with donor dendritic cells under blockade of cd40 pathway1.

2001年 | Transplantation 72(9), 1556-62  

その他

Takami H, Ikeda Y, Takayama J, Sasaki Y, Kan S, Niimi M, Inada E, Kameyama K. Adrenal-sparing adrenalectomy in hereditary bilateral phaeochromocytoma.

2001年 | ANZ J Surg 71(10), 623-4  

その他

Shirasugi N, Ikeda Y, Akiyama Y, Matsumoto K, Hamano K, Esato K, Bashuda H, Yagita H, Okumura K, Takami H, Kodaira S, Niimi M. Induction of hyporesponsiveness to fully allogeneic cardiac grafts by intratracheal delivery of alloantigen.

2001年 | Transplantation 71(4), 561-4  

その他

Niimi M, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Shatari T, Takami H, Kodaira S. Oral delivery of xeno-antigen combined with non-depleting anti-CD4 monoclonal antibody induces significantly prolonged survival of concordant skin xenograf

2001年 | Xenotransplantation 8(1), 75-9  

その他

Shirasugi N, Akiyama Y, Ikeda Y, Kan S, Hamano K, Takami H, Kodaira S, Niimi M. Intratracheal delivery of alloantigen induces donor-specific hyporesponsiveness: dendritic cells play a pivotal role as regulatory cells.

2001年 | Transplant Proc 33(1-2), 86  

その他

Ikeda Y, Niimi M, Kan S, Sasaki Y, Shatari T, Takami H, Kodaira S. Mediastinoscopic esophagectomy using carbon dioxide insufflation via the neck approach.

2001年 | Surgery 129(4), 504-6  

その他

Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y, Takayama J. Laparoscopic partial or cortical-sparing adrenalectomy by dividing the adrenal central vein.

2001年 | Surg Endosc 15(7), 747-50  

その他

Hara M, Kingsley CI, Niimi M, Read S, Turvey SE, Bushell AR, Morris PJ, Powrie F, Wood KJ. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.

2001年 | J Immunol 166(6), 3789-96  

その他

Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S. Clinical significance of tissue blood flow during esophagectomy by laser Doppler flowmetry.

2001年 | J Thorac Cardiovasc Surg 122(6), 1101-6  

その他

Ikeda Y, Niimi M, Sasaki Y, Shatari T, Takami H, Kodaira S. Thoracoscopic repair of a spontaneous perforation of the esophagus with the endoscopic suturing device.

2001年 | J Thorac Cardiovasc Surg 121(1), 178-9  

その他

Ikeda Y, Takami H, Niimi M, Kan S, Sasaki Y, Takayama J. Endoscopic thyroidectomy by the axillary approach.

2001年 | Surg Endosc 15(11), 1362-4  

その他

Niimi M, Roelen DL, Witzke O, van Rood JJ, Claas FH, Wood KJ. The importance of H2 haplotype sharing in the induction of specific unresponsiveness by pretransplant blood transfusions.

2000年 | Transplantation 69(3), 411-7  

その他

Niimi M, Takashina M, Takami H, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Shatari T, Kodaira S, Kameyama K. Experimental parathyroid transplantation: human parathyroid grafts survived and functioned in mice treated with anti-CD4 monoclona

2000年 | Biomed Pharmacother 54 Suppl 1, 80s-82s  

その他

Niimi M, Jones ND, Morris PJ, Wood KJ. Evidence that non-deletional mechanisms are responsible for inducing and maintaining unresponsiveness after intrathymic injection of non-professional antigen presenting cells.

2000年 | J Heart Lung Transplant 19(6), 576-83  

その他

Niimi M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Matsumoto K, Hamano K, Esato K, Hara M, Wood KJ. Oral administration of alloantigen plus nondepleting anti-CD4 monoclonal antibody induces indefinite prolongation of fully allogeneic card

2000年 | Transplant Proc 32(2), 259  

その他

Niimi M, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Shatari T, Takami H, Kodaira S. Oral delivery of xenoantigen combined with non-depleting anti-CD4 monoclonal antibody induced significant prolonged survival of concordant skin xenografts.

2000年 | Transplant Proc 32(5), 1035  

その他

Ikeda Y, Takami H, Sasaki Y, Kan S, Niimi M. Endoscopic neck surgery by the axillary approach.

2000年 | J Am Coll Surg 191(3), 336-40  

その他

Shirasugi N, Matsumoto S, Hamano K, Esato K, Matsumoto K, Bashuda H, Yagita H, Okumura K, Ikeda Y, Takami H, Kodaira S, Niimi M. Survival of fully allogeneic cardiac allografts induced by delivery of alloantigen via respiratory mucosa is abrogated by

2000年 | Transplant Proc 32(7), 2034  

その他

Lutz MB, Suri RM, Niimi M, Ogilvie AL, Kukutsch NA, Rossner S, Schuler G, Austyn JM. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo.

2000年 | Eur J Immunol 30(7), 1813-22  

その他

Gilot BJ, Hara M, Jones ND, van Maurik A, Niimi M, Hadjianastassiou V, Morris PJ, Wood KJ. Visualization of the in vivo generation of donor antigen-specific effector CD8+ T cells during mouse cardiac allograft rejection: in vivo effector CD8+ T cell

2000年 | Transplantation 69(4), 639-48  

その他

Ikeda Y, Takami H, Sasaki Y, Kan S, Niimi M. Endoscopic resection of thyroid tumors by the axillary approach.

2000年 | J Cardiovasc Surg (Torino) 41(5), 791-2  

その他

Shatari T, Niimi M, Fujita M, Kodaira S. Vascular anatomy of gracilis muscle: arterial findings to enhance graciloplasty.

2000年 | Surg Radiol Anat 22(1), 21-4  

その他

Niimi M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Matsumoto K, Hamano K, Esato K, Wood KJ. The thymus is essential for the development of operational tolerance induced by donor-specific transfusion plus anti-CD4 monoclonal antibody.

2000年 | Transplant Proc 32(7), 2067  

その他

Niimi M, Takashina M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Kameyama K, Matsumoto K, Hamano K, Esato K. Mice treated with anti-CD4 monoclonal antibody accept fully allogeneic thyroid grafts but reject second-donor-type thyroid grafts

2000年 | Transplant Proc 32(7), 2086  

その他

Niimi M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Matsumoto K, Hamano K, Esato K, Hara M, Wood KJ. Oral delivery of alloantigen combined with non-depleting anti-CD4 monoclonal antibody induces indefinite survival of cardiac allografts an

2000年 | Transplant Proc 32(7), 2035  

その他

Takami H, Shirahama S, Ikeda Y, Sasaki Y, Wada N, Niimi M, Kameyama K. Familial hyperparathyroidism.

2000年 | Biomed Pharmacother 54 Suppl 1, 21s-24s  

その他

Niimi M. [Organ transplantation and oral tolerance].

2000年 | Nihon Rinsho Meneki Gakkai Kaishi 23(6), 621-6  

その他

Niimi M, Takashina M, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Takami H, Kodaira S, Kameyama K. Human parathyroid grafts survived and functioned in mice treated with anti-CD4 monoclonal antibody.

2000年 | Transplant Proc 32(5), 1040  

その他

Niimi M, Ikeda Y, Shirasugi N, Shatari T, Takami H, Kodaira S, Matsumoto K, Hamano K, Esato K, Wood KJ. Intrathymic inoculation of donor B cells induced indefinite prolongation of fully allogeneic cardiac grafts but not islet or skin grafts.

2000年 | Transplant Proc 32(7), 2020  

その他

Niimi M, Witzke O, Bushell A, Hara M, Morris PJ, Wood KJ. Nondepleting anti-CD4 monoclonal antibody enhances the ability of oral alloantigen delivery to induce indefinite survival of cardiac allografts: oral tolerance to alloantigen.

2000年 | Transplantation 70(10), 1524-8  

その他

Niimi M, Takashina M, Takami H, Ikeda Y, Shatari T, Hamano K, Esato K, Matsumoto K, Kameyama K, Kodaira S, Wood KJ. Overexpression of heme oxygenase-1 protects allogeneic thyroid grafts from rejection in naive mice.

2000年 | Surgery 128(6), 910-7  

その他

Niimi M, Sato M, Yokote R, Tada S, Takahara J. Effects of central and peripheral injection of leptin on food intake and on brain Fos expression in the Otsuka Long-Evans Tokushima Fatty rat with hyperleptinaemia.

1999年 | J Neuroendocrinol 11(8), 605-11  

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Niimi M, Morris PJ, Wood KJ. Oral administration of alloantigen induces indefinite prolongation of MHC mismatched cardiac allografts.

1999年 | Transplant Proc 31(1-2), 892  

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Takami H, Ikeda Y, Niimi M. Ultrasonically activated scalpel for subtotal thyroidectomy in Graves' disease.

1999年 | Am J Surg 178(5), 433-4  

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Takami H, Niimi M, Ikeda Y. Prognosis of a family with familial medullary thyroid carcinoma.

1999年 | J Exp Clin Cancer Res 18(2), 223-4  

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Niimi M, Morris PJ, Wood KJ. Intrathymic inoculation of donor B cells prolongs cardiac allograft survival by non-deletional mechanisms.

1999年 | Transplant Proc 31(1-2), 94  

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Bushell A, Niimi M, Morris PJ, Wood KJ. Evidence for immune regulation in the induction of transplantation tolerance: a conditional but limited role for IL-4.

1999年 | J Immunol 162(3), 1359-66  

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An investigation to determine the ability of allogeneic resting B cells to induce specific unresponsiveness in vivo

1998年 | Oxford D-Phil thesis  

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Niimi M, Hara M, Witzke O, Morris PJ, Wood KJ. Donor resting B cells induce indefinite prolongation of fully allogeneic cardiac grafts when delivered with anti-immunoglobulin-D monoclonal antibody: evidence for tolerogenicity of donor resting B cells

1998年 | Transplantation 66(12), 1786-92  

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Niimi M, Pearson TC, Larsen CP, Alexander DZ, Hollenbaugh D, Aruffo A, Linsley PS, Thomas E, Campbell K, Fanslow WC, Geha RS, Morris PJ, Wood KJ. The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.

1998年 | J Immunol 161(10), 5331-7  

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Niimi M, Morris PJ, Wood KJ. Immunogenic (MHC class Ⅱ+) cells are able to induce unresponsiveness when delivered with anti-CD4 monoclonal antibody.

1998年 | Transplant Proc 30(5), 2450  

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Niimi M, Jones ND, Pajaro OB, Morris PJ, Wood KJ. Intrathymic administration of B cells induces prolonged survival of fully allogeneic cardiac grafts without prolonged deletion of donor-specific thymocytes.

1998年 | Transpl Immunol 6(3), 177-81  

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Roelen DL, Bushell AR, Niimi M, Young NT, Rust NA, Morris PJ, Wood KJ. Immunoregulation by CD4 T cells in the induction of specific immunological unresponsiveness to alloantigens in vivo: evidence for a reduction in the frequency of alloantigen-speci

1998年 | Hum Immunol 59(9), 529-39  

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Niimi K, Niimi M, Shepherd MG, Cannon RD. Regulation of N-acetylglucosaminidase production in Candida albicans.

1997年 | Arch Microbiol 168(6), 464-72  

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Niimi M, Roelen DL, Wong W, Hara M, Morris PJ, Wood KJ. Resting B cells as tolerogens in vivo but only for minor histocompatibility antigens: evidence for activation of resting B cells in vivo.

1997年 | Transplantation 64(9), 1330-5  

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Niimi M, Morris PJ, Wood KJ. Small, resting B cells induce prolonged survival of cardiac allografts mismatched for single minor, but not multiple minor, single major, or multiple major and minor histocompatibility antigens.

1997年 | Transplant Proc 29(1-2), 1171  

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Niimi M, Rawsthorne MA, Morris PJ, Wood KJ. B7-2+ low density APCS are as effective as B7-2- small resting B cells in inducing specific unresponsiveness to minor histocompatibility (miH) antigen(s) in vivo.

1997年 | Adv Exp Med Biol 417, 265-8  

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Roelen DL, Dover EL, Niimi M, Young NT, Morris PJ, Wood KJ. Semi-allogeneic (F1) versus fully allogeneic blood transfusions: differences in their ability to induce specific immunological unresponsiveness.

1996年 | Eur J Immunol 26(7), 1468-74  

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Akiyama Y, Shirasugi N, Uchida N, Matsumoto K, Kitajima M, Bashuda H, Yagita H, Okumura K, Aramaki O, Niimi M. B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice. Transplantation 2002;74(

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その他

Akiyama Y, Shibutani S, Matsumoto K, Kitajima M, Aramaki O, Yokoyama T, Kan S, Ikeda Y, Shirasugi N, Niimi M. CD25(+) regulatory cells generated by intratracheal delivery of alloantigen. Transplant Proc 2002;34(5):1443.

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Akiyama Y, Shibutani S, Matsumoto K, Kitajima M, Aramaki O, Yokoyama T, Kan S, Ikeda Y, Shirasugi N, Niimi M. Induction of prolonged survival of fully allogeneic cardiac graft by intratracheal delivery of a single major histocompatability complex cla

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その他

Akiyama Y, Shirasugi N, Aramaki O, Matsumoto K, Shimazu M, Kitajima M, Ikeda Y, Niimi M. Intratracheal delivery of a single major histocompatibility complex class I peptide induced prolonged survival of fully allogeneic cardiac grafts and generated r

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Aramaki O, Takayama T, Yokoyama T, Takano S, Akiyama Y, Shibutani S, Shirasugi N, Kan S, Ikeda Y, Niimi M. Intravenous administration of antithrombin III induces indefinite survival of fully allogeneic cardiac grafts. Transplant Proc 2002;34(5):1409.

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Aramaki O, Takayama T, Yokoyama T, Takano S, Akiyama Y, Shibutani S, Matsumoto K, Shimazu M, Kitajima M, Ikeda Y, Shirasugi N, Niimi M. High dose of antithrombin III induces indefinite survival of fully allogeneic cardiac grafts and generates regulat

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その他

Aramaki O, Shirasugi N, Akiyama Y, Shibutani S, Takayama T, Shimazu M, Kitajima M, Ikeda Y, Okumura K, Yagita H, Niimi M. CD27/CD70, CD134/CD134 ligand, and CD30/CD153 pathways are independently essential for generation of regulatory cells after intr

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その他

Aramaki O, Shirasugi N, Akiyama Y, Ikeda Y, Yabuki S, Shimazu M, Kitajima M, Niimi M, Shibutani S, Takayama T, Okumura K, Yagita H. Prolonged survival of fully allogeneic cardiac grafts in naive mice and those with sensitization induced by antigen de

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その他

Bushell A, Niimi M, Morris PJ, Wood KJ. Evidence for immune regulation in the induction of transplantation tolerance: a conditional but limited role for IL-4. J Immunol 1999;162(3):1359-66.

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その他

Gilot BJ, Hara M, Jones ND, van Maurik A, Niimi M, Hadjianastassiou V, Morris PJ, Wood KJ. Visualization of the in vivo generation of donor antigen-specific effector CD8+ T cells during mouse cardiac allograft rejection: in vivo effector CD8+ T cell

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Hara M, Kingsley CI, Niimi M, Read S, Turvey SE, Bushell AR, Morris PJ, Powrie F, Wood KJ. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001;166(6):3789-96.

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Ikeda Y, Takami H, Sasaki Y, Kan S, Niimi M. Endoscopic resection of thyroid tumors by the axillary approach. J Cardiovasc Surg (Torino) 2000;41(5):791-2.

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Ikeda Y, Takami H, Sasaki Y, Kan S, Niimi M. Endoscopic neck surgery by the axillary approach. J Am Coll Surg 2000;191(3):336-40.

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Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S. Clinical significance of tissue blood flow during esophagectomy by laser Doppler flowmetry. J Thorac Cardiovasc Surg 2001;122(6):1101-6.

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Ikeda Y, Takami H, Sasaki Y, Takayama J, Niimi M, Kan S. Clinical benefits in endoscopic thyroidectomy by the axillary approach. J Am Coll Surg 2003;196(2):189-95.

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Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S. Conformal radiation therapy for liver metastasis of esophageal carcinoma. Hepatogastroenterology 2003;50(50):532-4.

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Shatari T, Fujita M, Nozawa K, Haku K, Niimi M, Ikeda Y, et al. Vascular anatomy for right colon lymphadenectomy Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigenハ Induction of indefinite survival of ful

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その他

Aramaki O, Shirasugi N, Akiyama Y, Ikeda Y, Yabuki S, Shimazu M, Kitajima M, Niimi M, Shibutani S, Takayama T, Okumura K, Yagita H. Prolonged survival of fully allogeneic cardiac grafts in naive mice and those with sensitization induced by antigen de

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