Structural Analysis of Biomolecules |
UCHIDA, Kenichi |
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【Master's program･2nd semester】
19-3-1014-2342 |
| １． |
Outline |
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This course deals with the fundamentals of Nuclear Magnetic Resonance Spectroscopy (NMR), which is essential to elucidate structures of organic compounds. In order to learn the principle of NMR, it is necessary to understand the quantum mechanics. We will, however, focus on the techniques of structural determination which can be achieved by analyzing a set of 1D- and 2D-NMR spectra with minimum using mathematics.
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| ２． |
Objectives |
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At the end of the course, students are expected to elucidate the structure of small organic molecules by using NMR spectra.
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| ３． |
Grading Policy |
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Grading will be decided based on a lab report.
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| ４． |
Textbook and Reference |
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Nothing to use, but some optional documents may be provided.
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| ５． |
Requirements (Assignments) |
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Students should review the fundamentals of organic chemistry especially the molecular structure and isomers.
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| ６． |
Note |
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Nothing special.
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| ７． |
Schedule |
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１. Structures of molecule and Instrumental Analysis
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２. 1H-NMR 1: Interaction between nuclie and radio wave
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３. 1H-NMR 2: Chemical Shifts, Spin-spin interactions, Integral and Peak areas
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４. 1H-NMR 3: Spin systems
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５. 1H-NMR: Analysis of Spin systems
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６. 13C-NMR: FT-NMR
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７. 2D-NMR 1: COSY
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８. 2D-NMR 2: CH-COSY
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９. 2D-NMR 3: HMQC
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10. 2D-NMR 4: HMBC
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11. Nuclear Overhauser Effect (NOE)
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12. Structural determination 1: Method of structural determination using NMR
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13. Structural determination 2: Example of a simple molecule
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14. Structural determination 3: Example of a little bit complex molecule
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15. Summary and Examination
|
|
| １． |
Outline |
|
This course deals with the fundamentals of Nuclear Magnetic Resonance Spectroscopy (NMR), which is essential to elucidate structures of organic compounds. In order to learn the principle of NMR, it is necessary to understand the quantum mechanics. We will, however, focus on the techniques of structural determination which can be achieved by analyzing a set of 1D- and 2D-NMR spectra with minimum using mathematics.
|
| ２． |
Objectives |
|
At the end of the course, students are expected to elucidate the structure of small organic molecules by using NMR spectra.
|
| ３． |
Grading Policy |
|
Grading will be decided based on a lab report.
|
| ４． |
Textbook and Reference |
|
Nothing to use, but some optional documents may be provided.
|
| ５． |
Requirements (Assignments) |
|
Students should review the fundamentals of organic chemistry especially the molecular structure and isomers.
|
| ６． |
Note |
|
Nothing special.
|
| ７． |
Schedule |
|
１. Structures of molecule and Instrumental Analysis
|
２. 1H-NMR 1: Interaction between nuclie and radio wave
|
３. 1H-NMR 2: Chemical Shifts, Spin-spin interactions, Integral and Peak areas
|
４. 1H-NMR 3: Spin systems
|
５. 1H-NMR: Analysis of Spin systems
|
６. 13C-NMR: FT-NMR
|
７. 2D-NMR 1: COSY
|
８. 2D-NMR 2: CH-COSY
|
９. 2D-NMR 3: HMQC
|
10. 2D-NMR 4: HMBC
|
11. Nuclear Overhauser Effect (NOE)
|
12. Structural determination 1: Method of structural determination using NMR
|
13. Structural determination 2: Example of a simple molecule
|
14. Structural determination 3: Example of a little bit complex molecule
|
15. Summary and Examination
|
|
|