Bioorganic Chemistry

SAKUDA, Shohei
  Elective  2 credits
【Biosciences・1st semester】
19-1-1852-4887

1.
Outline
Biosynthesis, bioactivities and modes of action of bioactive compounds, which have key roles in a variety of organisms such as mammals, insects, plants, and microorganisms are studied. Skills obtained in this class are related to DP2 and DP3.
2.
Objectives
General biosynthetic pathways such as polyketide pathway and mevalonic pathway are studied to understand how bioactive compounds are biosynthesized. Structures, biosynthesis, bioactivities, and modes of action of various bioactive compounds such as insect hormones and signal molecules of microbes are studied to know the functions of bioactive compounds in each organism.
3.
Grading Policy
Quiz every time: 40%
Finals: 60%

4.
Textbook and Reference
Hnadouts are used.
Reference book: "Chemistry and Biology of Bioactive Compounds" Hiromich Nagasawa, TERRAPUB, ISBN-10: 4887041667

5.
Requirements (Assignments)
Please review organic chemistry and biochemistry already learned.

6.
Note
N/A
7.
Schedule
1. Learn about what bioorganic chemistry is.

2. Learn about classification of bioactive compounds and how to study them.

3. Learn about biosynthesis of fatty acids.

4. Learn about polyketide pathway.

5. Learn about mevalonic pathway.

6. Learn about isoprenoides.

7. Learn about shikimic acid pathway.

8. Learn about biosynthesis of sugars and peptides.

9. Learn about methods used for biosynthetic research.

10. Learn about insect hormones and pheromones.

11. Learn about bioactive compounds produced by plants and microbes.

12. Learn about microbial signal molecules.

13. Learn about bioactive compounds produced by microbes.

14. Learn about toxic compounds produced by a variety of organisms.

15. Finals and explanation.

1.
Outline
Biosynthesis, bioactivities and modes of action of bioactive compounds, which have key roles in a variety of organisms such as mammals, insects, plants, and microorganisms are studied. Skills obtained in this class are related to DP2 and DP3.
2.
Objectives
General biosynthetic pathways such as polyketide pathway and mevalonic pathway are studied to understand how bioactive compounds are biosynthesized. Structures, biosynthesis, bioactivities, and modes of action of various bioactive compounds such as insect hormones and signal molecules of microbes are studied to know the functions of bioactive compounds in each organism.
3.
Grading Policy
Quiz every time: 40%
Finals: 60%

4.
Textbook and Reference
Hnadouts are used.
Reference book: "Chemistry and Biology of Bioactive Compounds" Hiromich Nagasawa, TERRAPUB, ISBN-10: 4887041667

5.
Requirements (Assignments)
Please review organic chemistry and biochemistry already learned.

6.
Note
N/A
7.
Schedule
1. Learn about what bioorganic chemistry is.

2. Learn about classification of bioactive compounds and how to study them.

3. Learn about biosynthesis of fatty acids.

4. Learn about polyketide pathway.

5. Learn about mevalonic pathway.

6. Learn about isoprenoides.

7. Learn about shikimic acid pathway.

8. Learn about biosynthesis of sugars and peptides.

9. Learn about methods used for biosynthetic research.

10. Learn about insect hormones and pheromones.

11. Learn about bioactive compounds produced by plants and microbes.

12. Learn about microbial signal molecules.

13. Learn about bioactive compounds produced by microbes.

14. Learn about toxic compounds produced by a variety of organisms.

15. Finals and explanation.